CHRONIC GRAFT VERSUS HOST DISEASE

This study tests a combination of two drugs, belumosudil and rituximab, as the first treatment for people with chronic graft-versus-host disease (cGVHD), a complication after a stem cell transplant. The goal is to see if this approach can control the disease and reduce the need f…

This study tests whether adding axatilimab to the standard drug ruxolitinib works better for people with newly diagnosed chronic graft-versus-host disease (cGVHD), a complication after stem cell transplant. About 120 participants aged 12 and older will receive the combination or …

This study tests whether the drug belumosudil can prevent chronic graft-versus-host disease (cGVHD) in people who have had a stem cell transplant. cGVHD is a common complication where the donor's immune cells attack the patient's body. Belumosudil works by calming the immune resp…

This study tests a new drug called axatilimab against the best current treatments for children aged 2 to 17 with chronic graft-versus-host disease (cGVHD), a serious complication after a stem cell transplant. Participants must have already tried at least two prior treatments. The…

This study tests whether the drug ibrutinib can prevent chronic graft-versus-host disease (GVHD) in people who have received a donor stem cell transplant. GVHD happens when the donor cells attack the patient's body. Ibrutinib blocks a protein that may help stop this attack. The t…

This study tests whether adding the drug axatilimab to a standard light-based blood treatment (ECP) can better control chronic graft-versus-host disease (cGVHD), a long-term complication after a stem cell transplant. About 49 people aged 12 and older who have already tried at lea…

This study tests whether adding the drug axatilimab to standard steroid treatment helps people with moderate to severe chronic graft-versus-host disease (cGVHD), a complication after a stem cell transplant. About 240 participants aged 12 and older will receive either axatilimab o…

This early-stage trial tests an experimental drug called Q702 in 18 adults with chronic graft-versus-host disease (cGVHD) that has not responded to standard treatments. The main goal is to find a safe dose and check for side effects. Researchers will also look at how the drug mov…

This study tests a drug called belumosudil in children aged 1 to 18 who have moderate-to-severe chronic graft-versus-host disease (cGVHD) after a stem cell transplant. The disease has not improved with at least two prior treatments. The goal is to find the right dose and see if t…

This study tests a drug called axatilimab for people whose skin becomes thick and hard after a donor stem cell transplant, a condition called sclerotic chronic graft-versus-host disease. About 50 adults will receive the drug to see if it can improve skin symptoms and prevent furt…

This early-phase study tests a combination of two drugs, ruxolitinib and fostamatinib, for people with chronic graft-versus-host disease (cGVHD) that hasn't responded well to steroids. cGVHD is a complication after a stem cell transplant where the donor's immune cells attack the …

This study offers ongoing access to the drug ibrutinib for up to 700 people with certain blood cancers (like chronic lymphocytic leukemia or mantle cell lymphoma) who are already taking it and benefiting. The goal is to track long-term safety and see how well the drug controls th…

This study tests a new drug called belumosudil for people who develop a serious lung condition (bronchiolitis obliterans syndrome) after a stem cell transplant. The goal is to see if the drug can improve lung function or slow the disease. About 45 adults with new or early-stage l…

This study tests a drug called axatilimab in Chinese patients who have chronic graft-versus-host disease (cGVHD) that did not get better with other treatments. cGVHD is a complication after a stem cell transplant where the donor cells attack the patient's body. The goal is to see…

This study tests whether a dental cleaning shortly after a stem cell transplant can prevent chronic graft-versus-host disease (GVHD), a serious condition where donor cells attack the patient's body. About 45 adults receiving a stem cell transplant for blood cancer will get a post…

This study tests whether a home-based aerobic and resistance exercise program is feasible for adults with graft-versus-host disease (GVHD) who are starting high-dose steroids after a stem cell transplant. The goal is to see if exercise can help manage complications like high bloo…

This study enrolls 300 adults with chronic graft-versus-host disease (cGVHD) who are about to start a new treatment. Researchers collect blood samples and clinical data before and after treatment to identify changes that might predict how well a person will respond. The goal is t…

This study looks at whether crushing belumosudil tablets affects how the drug is absorbed in people with chronic graft-versus-host disease (cGVHD). Eight adults who have had a stem cell transplant will take the drug as a whole tablet and later as a crushed tablet in water. The go…