CHRONIC GRAFT-VERSUS-HOST-DISEASE
Clinical trials for CHRONIC GRAFT-VERSUS-HOST-DISEASE explained in plain language.
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Rollover study offers continued itacitinib access for chronic disease patients
Disease control TerminatedThis study provides continued access to itacitinib for 18 patients who were already benefiting from the drug in earlier trials. Participants have myelofibrosis, chronic graft-versus-host disease, or bronchiolitis obliterans after lung transplant. They continue their same dose as …
Matched conditions: CHRONIC GRAFT-VERSUS-HOST-DISEASE
Phase: PHASE2 • Sponsor: Incyte Corporation • Aim: Disease control
Last updated Jun 28, 2026 00:00 UTC
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Promising GVHD prevention trial halted early – too few patients to draw conclusions
Disease control TerminatedThis phase II trial tested whether the drug ibrutinib could prevent chronic graft-versus-host disease (GVHD) in adults who had received a donor stem cell transplant. Only 2 people enrolled before the study was terminated early. Because of the very small number of participants, no…
Matched conditions: CHRONIC GRAFT-VERSUS-HOST-DISEASE
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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Steroid-Free hope? early trial of ruxolitinib for young GVHD patients ends prematurely
Disease control TerminatedThis pilot study tested whether the drug ruxolitinib could be used as the first treatment for chronic graft-versus-host disease (cGVHD) in children and young adults, instead of the usual high-dose steroids. The goal was to see if it could control the disease while avoiding steroi…
Matched conditions: CHRONIC GRAFT-VERSUS-HOST-DISEASE
Phase: PHASE1 • Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Disease control
Last updated Jun 27, 2026 09:07 UTC
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New drug combo for transplant complication shows promise but study halted
Disease control TerminatedThis study tested whether adding itacitinib (an anti-inflammatory drug) to standard steroid treatment could help people with moderate to severe chronic graft-versus-host disease (cGVHD), a complication after stem cell transplants. The trial enrolled 155 participants but was termi…
Matched conditions: CHRONIC GRAFT-VERSUS-HOST-DISEASE
Phase: PHASE2, PHASE3 • Sponsor: Incyte Corporation • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
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Light therapy study sheds light on immune changes in transplant complication
Knowledge-focused TerminatedThis study looked at how extracorporeal photopheresis (ECP) — a treatment that uses light to modify a patient's own blood cells — affects the immune system in people with chronic graft-versus-host disease (cGVHD), a complication after a stem cell transplant. Only 8 people were en…
Matched conditions: CHRONIC GRAFT-VERSUS-HOST-DISEASE
Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC