CHRONIC GRAFT VERSUS HOST DISEASE

This study is testing an oral drug called TQ05105 for adults with a serious complication called chronic graft-versus-host disease (cGVHD) that has not responded well to standard steroid treatment. The trial aims to find a safe and effective dose and see if the drug can help contr…

This study allows people who were already receiving itacitinib in previous clinical trials to continue taking the medication. It's for adults with myelofibrosis, chronic graft-versus-host disease, or lung transplant complications who were benefiting from the drug in earlier studi…

This study tested a daily low-dose injection of a drug called IL-2 for people with chronic graft-versus-host disease (cGVHD) who did not respond well to standard steroid treatment. The goal was to see if adding IL-2 could help control the condition and allow doctors to reduce ste…

This study is testing whether an investigational drug called axatilimab works better than the best currently available treatments for chronic graft-versus-host disease (cGVHD). It is for patients aged 12 and older whose cGVHD has not improved after at least two prior drug treatme…

This study is testing whether adding the drug belumosudil to standard steroid treatment works better than steroids alone for people newly diagnosed with moderate or severe chronic graft-versus-host disease (cGVHD). cGVHD is a serious complication that can occur after a stem cell …

This early-stage safety study is testing a new combination treatment for chronic graft-versus-host disease (cGVHD) that doesn't improve with standard steroid therapy. The treatment involves giving patients special anti-inflammatory immune cells (Tregs) collected from their origin…

This study is testing a drug called axatilimab for Japanese patients with chronic graft-versus-host disease (cGVHD) that has come back or hasn't improved after at least two prior treatments. The goal is to see if the drug can reduce the severity of the disease and improve symptom…

This early-stage trial is testing a new cell therapy for patients with chronic graft-versus-host disease (cGVHD), a serious complication where donor immune cells attack the patient's body after a bone marrow transplant. Researchers modify a donor's immune cells in the lab to crea…

This study is testing a drug called axatilimab for people with chronic graft-versus-host disease (cGVHD) that has come back or hasn't improved after trying at least two other treatments. The goal is to see if the drug can reduce the disease's severity and symptoms, and to find th…

This study aimed to test the safety and effectiveness of an oral drug called belumosudil for people with chronic graft-versus-host disease (cGVHD), a serious complication after a stem cell or bone marrow transplant. It specifically focused on recruiting Black, African American, A…

This early-stage study is testing an oral drug called alvelestat for people who develop a serious lung scarring condition (BOS) after a stem cell transplant. The goal is to find a safe dose that blocks a harmful enzyme thought to cause the lung damage and to see if that dose can …

This study is testing whether a mobile phone app called 'Horizons' can help people who are living with chronic graft-versus-host disease (GVHD) after a stem cell transplant. About 120 adult patients will be randomly assigned to either use the app along with their usual care, or t…

This small study is testing whether monthly video calls with palliative care specialists are a practical and helpful way to support adults with moderate to severe chronic graft-versus-host disease (cGVHD). The goal is to help patients better manage their complex symptoms, reduce …

This study aims to understand the role of specific immune cells, called dendritic cells, in the development of skin graft-versus-host disease (GVHD) after a bone marrow transplant. Researchers will collect and analyze small skin samples from 22 adult patients who have either acut…

This study aims to improve how doctors measure and understand chronic graft-versus-host disease (GVHD), a serious and long-lasting complication of stem cell transplants. Researchers will follow over 600 people with chronic GVHD for several years, collecting detailed information f…