CHRONIC GRAFT VERSUS HOST DISEASE

This early-stage trial tests a new treatment called CD6-CAR Tregs for people with chronic graft-versus-host disease (cGVHD), a complication after a stem cell transplant. The therapy uses specially modified immune cells to calm the overactive immune response that causes cGVHD. The…

This study tests an oral drug called alvelestat in people who developed bronchiolitis obliterans syndrome (BOS) after a stem cell transplant. BOS causes lung damage and breathing problems. The goal is to find a safe dose that blocks a harmful enzyme and improves lung function. Ab…

This study tests an experimental tablet called TQ05105 in 45 adults with moderate to severe chronic graft-versus-host disease (cGVHD) that hasn't improved with steroids. The goal is to find the safest dose and see if it can control the disease. Participants take the pill by mouth…

This study gives continued access to itacitinib for 18 patients who were already benefiting from the drug in earlier trials. It covers three serious conditions: myelofibrosis (a bone marrow disorder), bronchiolitis obliterans after lung transplant, and chronic graft-versus-host d…

This study aimed to test the safety and effectiveness of the oral drug belumosudil in Black, American Indian, Alaska Native, Native Hawaiian, and Pacific Islander people aged 12 and older with chronic graft-versus-host disease (cGVHD) after at least two prior treatments. Particip…

This study tests a new drug called axatilimab against the best available treatments for people with chronic graft-versus-host disease (cGVHD) who have already tried at least two other therapies. cGVHD is a condition where donor immune cells attack the patient's body after a stem …

This study tests a drug called axatilimab in Japanese patients with chronic graft-versus-host disease (cGVHD) that has not responded to at least two prior treatments. cGVHD is a serious complication after a stem cell transplant where the donor cells attack the patient's body. The…

This study tested a daily low-dose injection of IL-2 in 35 people with chronic graft-versus-host disease (cGVHD) that did not respond to steroids. cGVHD is a complication after a stem cell or bone marrow transplant where the donor's immune cells attack the recipient's body. The g…

This study tests whether adding the drug belumosudil to standard steroids helps control chronic graft-versus-host disease (cGVHD) better than steroids alone. cGVHD is a long-term complication after a stem cell transplant where the donor cells attack the patient's body. The trial …

This early-stage trial tests a combination of donor immune cells (Tregs) and a low-dose protein (IL-2) to control chronic graft-versus-host disease (cGVHD), a condition where donor cells attack the recipient's body after a stem cell transplant. The study includes 25 people whose …

This study tests a drug called axatilimab in 241 people with chronic graft-versus-host disease (cGVHD), a complication after a stem cell transplant where donor cells attack the body. Participants had already tried at least two other treatments without success. The goal is to see …

This study tests whether a mobile app called Horizons can improve quality of life and reduce distress for people with chronic graft-versus-host disease (GVHD) after a stem cell transplant. About 120 adults with moderate to severe chronic GVHD will use the app or receive usual car…

This study looks at whether a palliative care program delivered via video calls is practical and well-received by people with moderate to severe chronic graft-versus-host disease (cGVHD), a complication after a stem cell transplant. Ten adults will participate in up to three tele…

This study tests whether a mobile app called Horizons can help improve quality of life for adults who have chronic graft-versus-host disease after a stem cell transplant. About 20 participants will use the app and complete surveys. The goal is to see if the app is easy to use and…

This study looks at how different types of immune cells (dendritic cells) in the skin are involved in graft-versus-host disease (GVHD) after a bone marrow transplant. Researchers will collect skin samples and blood from 22 adults with acute or chronic skin GVHD to analyze cell ty…

This study looks at whether new NIH guidelines can help doctors better diagnose and track chronic graft-versus-host disease (GVHD), a common complication after stem cell transplants. Researchers will follow 601 patients over several years, collecting information from doctors, pat…