New tool aims to measure Kids' GVHD symptoms more accurately

NCT ID NCT04044365

Ongoing Knowledge-focused Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 11, 2026 · Updated 5 times

Summary

This study aims to create a symptom questionnaire specifically for children and teens living with chronic graft-versus-host disease (cGVHD) after a stem cell transplant. Current symptom scales are designed for adults, but children may describe their symptoms differently. Researchers will interview children aged 5-17 and their parents to develop and test a new scale that better captures how bothersome symptoms are, with the goal of improving care and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could give doctors a better tool to understand and manage symptoms in children with chronic GVHD, improving their quality of life.
What could go wrong: This is an early-stage study focused on developing a questionnaire, not testing a treatment. It may not lead to direct improvements in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic graft versus host disease graft versus host disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GRAFT VS HOST DISEASE

Contacts and locations

Locations

Children s National Medical Center (CNMC)

Washington D.C., District of Columbia, 20010, United States
Children's & Women's Health Centre of British Columbia (CWHC of BC)

Vancouver BC, Canada
Children's Healthcare of Atlanta - Egleston Hospital

Atlanta, Georgia, 30322, United States
Children's Hospital Colorado (CHCO)

Aurora, Colorado, 80045, United States
Children's Wisconsin

Milwaukee, Wisconsin, 53226, United States
City of Hope

Duarte, California, 91010, United States
Fred Hutchinson Cancer Center (FHCC)

Seattle, Washington, 98109, United States
Hospital for Sick Children (SickKids)

Toronto, Canada
Johns Hopkins Hospital (JHH)

Baltimore, Maryland, 21287, United States
Lurie Children's Hospital of Chicago

Chicago, Illinois, 60611, United States
National Institutes of Health Clinical Center

Bethesda, Maryland, 20892, United States
Phoenix Children's Hospital

Phoenix, Arizona, 85016, United States
St. Jude Children s Research Hospital

Memphis, Tennessee, 38105, United States
Texas Children's Hospital (TCH)-Baylor

Houston, Texas, 77030, United States
The University of Texas MD Anderson Cancer Institute

Houston, Texas, 77030, United States
University of Minnesota

Minneapolis, Minnesota, 55455, United States
University of Pittsburgh - Children's Hospital of Pittsburgh

Pittsburgh, Pennsylvania, 15224, United States

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