GRAFT VS. HOST DISEASE

This study is testing the drug ruxolitinib in Chinese adults and adolescents (aged 12+) who have chronic graft-versus-host disease (cGvHD) that does not improve with standard steroid treatment. The goal is to see if ruxolitinib can help control the disease and reduce symptoms. Ab…

This early-stage study is testing whether adding one or two drugs to standard treatment can better prevent two serious complications that can occur after a half-matched stem cell transplant for blood cancers. The complications are graft-versus-host disease (where donor cells atta…

This early-stage study is testing a new type of stem cell transplant for adults with aggressive or hard-to-treat forms of acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). The goal is to see if adding special donor immune cells can help the transplant fight the can…

This study is for patients who develop a severe, life-threatening immune reaction (GVHD) after a stem cell transplant that doesn't respond to standard steroid treatment. It will test if adding a drug called etanercept to the current standard drug, ruxolitinib, works better than r…

This study is testing an oral drug called pacritinib for people with chronic graft-versus-host disease (cGVHD) that hasn't improved after at least two other treatments. cGVHD is a serious immune system complication that can occur after a stem cell transplant. The trial aims to se…

This study is testing whether giving a drug called abatacept for a longer period of time is better at preventing severe complications after a stem cell transplant. It will involve about 160 patients, aged 2 and up, who have a blood cancer and are receiving a transplant from a par…

This study is testing whether adding the drug belumosudil to standard preventive treatments can better protect blood cancer patients from graft-versus-host disease (GVHD) after a stem cell transplant. Researchers will enroll 46 adults who have recently received a transplant and a…

This study is testing if a home-based exercise program can help patients who develop Graft-Versus-Host Disease (GVHD) after a stem cell transplant. The goal is to see if exercise can improve blood sugar control, body composition, fitness, and quality of life while patients are on…

This study aims to understand a painful complication called vulvovaginal graft-versus-host disease (GVHD) that can occur after a stem cell transplant. Researchers will observe 40 women to see if the community of bacteria in the vagina changes after the transplant and if those cha…

This study aims to create and test a new questionnaire specifically for children and teens living with chronic graft-versus-host disease (cGVHD), a serious and often painful side effect of stem cell transplants. Researchers will work with 420 children (ages 5-17) and their parent…

This study aims to understand why some people experience severe fatigue and thinking problems after stem cell transplants. Researchers will examine 30 transplant survivors to see if brain inflammation might be causing these symptoms. They'll use brain scans and spinal fluid tests…

This study follows 1,000 patients for years after they received donor stem cell transplants to monitor their long-term health. Participants receive regular check-ups and tests to track any late-developing complications from their transplant. The goal is to better understand the l…