Extended drug regimen may shield transplant patients from deadly immune attack
NCT ID NCT04380740
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether giving more doses of the drug abatacept over a longer period can better prevent graft-versus-host disease (GVHD), a serious complication where donor immune cells attack the patient's body. About 160 people receiving stem cell transplants from partially matched donors will be randomly assigned to either a standard short course or an extended course of abatacept, alongside usual medications. The goal is to see if the extended regimen improves survival without severe GVHD or relapse.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Beth Israel Deaconess Medical Center
ACTIVE_NOT_RECRUITINGBoston, Massachusetts, 02215, United States
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Boston Children's Hospital
RECRUITINGBoston, Massachusetts, 02115, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Children's Healthcare of Atlanta
RECRUITINGAtlanta, Georgia, 30329, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Children's Hospital of Philadelphia
WITHDRAWNPhiladelphia, Pennsylvania, 19104, United States
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Cincinnati Children's Hospital
ACTIVE_NOT_RECRUITINGCincinnati, Ohio, 45229, United States
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City Of Hope National Medical Center
ACTIVE_NOT_RECRUITINGDuarte, California, 91010, United States
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Dana-Farber Cancer Institute
ACTIVE_NOT_RECRUITINGBoston, Massachusetts, 02215, United States
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Emory University/Winship Cancer Center
ACTIVE_NOT_RECRUITINGAtlanta, Georgia, 30322, United States
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Massachusetts General Hospital
ACTIVE_NOT_RECRUITINGBoston, Massachusetts, 02114, United States
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Moffitt Cancer Center
ACTIVE_NOT_RECRUITINGTampa, Florida, 33612, United States
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Oregon Health and Sciences University
ACTIVE_NOT_RECRUITINGPortland, Oregon, 97239, United States
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University of Chicago
RECRUITINGChicago, Illinois, 60637, United States
Contact
Contact
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University of Michigan
ACTIVE_NOT_RECRUITINGAnn Arbor, Michigan, 48109, United States
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University of Rochester
RECRUITINGRochester, New York, 14642, United States
Contact Email: •••••@•••••
Contact
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Washington University St. Louis
WITHDRAWNSt Louis, Missouri, 63110, United States