New drug may help lung damage after stem cell transplants
NCT ID NCT02669251
First seen Jun 25, 2026 · Last updated Jul 29, 2026 · Updated 4 times
Summary
This study tests a new oral drug called alvelestat (MPH966) in adults who have lung damage (bronchiolitis obliterans syndrome) after a stem cell transplant. The drug aims to block an enzyme that may cause lung injury. The trial has two parts: first to find the safest and most effective dose, then to see if that dose improves lung function over up to 12 months. Only 14 participants are enrolled, so results are very early.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- alvelestat (MPH966)
- What this could lead to
- If it works, this could point toward a treatment to slow or improve lung damage in people with bronchiolitis obliterans syndrome after a stem cell transplant.
- What could go wrong
- This is an early, small trial with only 14 participants, so results may not apply to everyone. The drug may not improve lung function or could cause side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can lung MRI replace CT scans for detecting a serious Post-Transplant lung condition?