New drug axatilimab tested for Hard-to-Treat Graft-Versus-Host disease in china

NCT ID NCT06843408

Ongoing Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 2 times

Summary

This study tests a drug called axatilimab in 30 Chinese patients with chronic graft-versus-host disease (cGVHD) that has come back or not improved after standard treatment. cGVHD is a complication of bone marrow or stem cell transplants where donor cells attack the patient's body. The trial aims to see if axatilimab is safe and can help control the disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: axatilimab
What this could lead to: If successful, this could provide a new treatment option for Chinese patients with chronic graft-versus-host disease that hasn't responded to other therapies.
What could go wrong: This is an early-phase trial with only 30 participants, so results may not apply broadly. Side effects are possible, and the drug may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Bronchiolitis Obliterans Syndrome chronic graft versus host disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC GRAFT VERSUS HOST DISEASE

Contacts and locations

Locations

Institute of Hematology, Chinese Academy of Medical Sciences

Tianjin, 301617, China
Nanfang Hospital of Southern Medical University

Guangzhou, 510515, China
Peking University People'S Hospital

Beijing, 101149, China
Shanghai Children'S Medical Center

Shanghai, 200127, China
The First Affiliated Hospital, Zhejiang University School of Medicine

Hangzhou, 310024, China
The Second Affiliated Hospital, Army Medical University (Xinqiao Hospital)

Chongoing, 400037, China
Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology

Wuhan, 430022, China
West China Hospital of Sichuan University

Chengdu, 610041, China
Zhujiang Hospital of Southern Medical University

Guangzhou, 510280, China

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