Could an arthritis drug tame a tough transplant complication?
NCT ID NCT01954979
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests the drug abatacept in people with chronic graft-versus-host disease (cGVHD) that is not controlled by steroids. cGVHD is a condition where donor immune cells attack the recipient's body after a stem cell transplant. The trial has two phases: first, to find a safe dose of abatacept, and second, to see if it helps control the disease. Fifty-six participants will receive abatacept and be monitored for side effects and response.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- abatacept
- What this could lead to
- If it works, this could offer a new treatment option for people with chronic graft-versus-host disease that does not respond to standard steroids.
- What could go wrong
- This is an early-phase trial with only 56 participants, so results may not apply to everyone. Abatacept can cause serious immune suppression and side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
-
Dana-Farber Cancer Institute
Boston, Massachusetts, 02115, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can meditation tame the Long-Term side effects of a stem cell transplant?
- Could a liquid form of a Graft-Versus-Host disease drug be as effective as the pill?
- Scientists map immune battlefield in chronic GVHD tissue
- Could a rheumatoid arthritis drug tame chronic GVHD and cut steroid use?
- New hope for teens with chronic Graft-Versus-Host disease: belumosudil under study
- Herbal extract shows promise for stiff skin and joints in transplant survivors