New pill shows promise for Hard-to-Treat transplant complication
NCT ID NCT04944043
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a new tablet called TQ05105 in 45 adults with moderate to severe chronic graft-versus-host disease (cGVHD) that hasn't responded to steroids. The drug works by blocking a protein pathway involved in inflammation. The goal is to find the right dose and see if it can control the disease, potentially reducing the need for steroids.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- TQ05105 tablet (a JAK inhibitor)
- What this could lead to
- If successful, this could offer a new treatment option for people with chronic graft-versus-host disease that doesn't respond to steroids, helping control the condition and reduce steroid dependence.
- What could go wrong
- This is an early-phase trial with only 45 participants, so results may not apply to everyone. The drug may cause side effects or fail to improve outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Guangzhou First People's Hospital
Guangzhou, Guangdong, 511457, China
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Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
Tianjin, Tianjin Municipality, 300020, China
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Nanfang Hospital of Southern Medical University
Guangzhou, Guangdong, 510515, China
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The First Affiliated Hospital of Guangxi Medical University
Nanning, Guangxi, 530021, China
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The First Affiliated Hospital of Soochow University
Suzhou, Jiangsu, 215006, China
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The First Affiliated Hospital of USTC (Anhui Provincial Hospital)
Hefei, Anhui, 230001, China
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The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, 450052, China
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The First Affiliated Hospital, Zhejiang University School of Medicine
Hanzhou, Zhejiang, 310000, China
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The Second Hospital of Hebei Medical University
Shijiazhuang, Hebei, 050000, China
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Tongji Hospital Tongji Medical College of HUST
Wuhan, Hubei, 430030, China
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Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, Hubei, 430022, China
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Zhujiang Hospital of Southern Medical University
Guangzhou, Guangdong, 510280, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can meditation tame the Long-Term side effects of a stem cell transplant?
- Could a liquid form of a Graft-Versus-Host disease drug be as effective as the pill?
- Scientists map immune battlefield in chronic GVHD tissue
- Could a rheumatoid arthritis drug tame chronic GVHD and cut steroid use?
- Could an arthritis drug tame a tough transplant complication?
- New hope for teens with chronic Graft-Versus-Host disease: belumosudil under study