Can a blood test predict which cGVHD treatment works best?
NCT ID NCT04431479
First seen Jun 25, 2026 · Last updated Jul 10, 2026 · Updated 2 times
Summary
This study enrolls 300 adults with chronic graft-versus-host disease (cGVHD) who are about to start a new therapy. Researchers will collect blood samples and medical data before and after treatment to look for changes that might predict how well a patient responds. The goal is to find markers that could guide treatment decisions in the future.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this could help doctors choose the most effective treatment for each patient with chronic graft-versus-host disease, improving outcomes and reducing trial-and-error.
- What could go wrong
- This is an observational study, not a treatment trial. It may not identify reliable predictors, and results may not change clinical practice for years.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
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Dana-Farber Harvard Cancer Center
Boston, Massachusetts, 02115, United States
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Fred Hutch/University of Washington Cancer Consortium
Seattle, Washington, 98109, United States
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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Roswell Park Cancer Institute
Buffalo, New York, 14263, United States
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UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, 15232, United States
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University of Florida
Gainesville, Florida, 32610, United States
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University of Minnesota/Masonic Cancer Center
Minneapolis, Minnesota, 55455, United States
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Vancouver General Hospital/BC Cancer
Vancouver, British Columbia, V5Z 4E6, Canada
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Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, 37232, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can meditation tame the Long-Term side effects of a stem cell transplant?
- Could a liquid form of a Graft-Versus-Host disease drug be as effective as the pill?
- Scientists map immune battlefield in chronic GVHD tissue
- Could a rheumatoid arthritis drug tame chronic GVHD and cut steroid use?
- Could an arthritis drug tame a tough transplant complication?
- New hope for teens with chronic Graft-Versus-Host disease: belumosudil under study