New hope for japanese patients with Hard-to-Treat chronic GVHD
NCT ID NCT06263478
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a drug called axatilimab in Japanese patients with chronic graft-versus-host disease (cGVHD) that has not improved after at least two prior treatments. cGVHD is a complication of stem cell transplants where donor cells attack the patient's body. The goal is to see if axatilimab can control the disease and improve symptoms. About 21 participants aged 6 and older will take part.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Fujita Health University Hospital
Aichi, 470-1192, Japan
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Hiroshima University Hospital
Hiroshima, 734-8551, Japan
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Hokkaido University Hospital
Hokkaido, 060-8648, Japan
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Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital
Nagoya, 453-8511, Japan
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Kobe City Medical Center General Hospital
Hyōgo, 650-0047, Japan
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Kyushu University Hospital
Fukuoka, Japan
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National Center For Child Health and Development
Tokyo, 157-8535, Japan
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National Hospital Organization Kumamoto Medical Center
Kumamoto, 860-0008, Japan
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Okayama University Hospital
Okayama, 700-8558, Japan
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Osaka Metropolitan University Hospital
Osaka, 545-8586, Japan
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Osaka Prefectural Hospital Organization Osaka International Cancer Institute
Osaka, 541-8567, Japan
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Saitama Prefectural Children'S Medical Center
Saitama-shi, Saitama,, 330-8777, Japan
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Tohoku University Hospital
Miyagi, 980-8574, Japan
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Tokai University Hospital
Kanagawa, 259-1193, Japan
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Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital
Tokyo, 113-8677, Japan
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University of Fukui Hospital
Fukui, 910-1193, Japan
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can meditation tame the Long-Term side effects of a stem cell transplant?
- Could a liquid form of a Graft-Versus-Host disease drug be as effective as the pill?
- Scientists map immune battlefield in chronic GVHD tissue
- Could a rheumatoid arthritis drug tame chronic GVHD and cut steroid use?
- Could an arthritis drug tame a tough transplant complication?
- New hope for teens with chronic Graft-Versus-Host disease: belumosudil under study