New combo therapy aims to tame chronic GVHD

NCT ID NCT06663722

Recruiting now Disease control Sponsor: University of Miami Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether combining a drug called axatilimab with a blood-filtering procedure (ECP) can help people with chronic graft-versus-host disease (cGVHD), a complication after a stem cell transplant. About 49 participants who have tried at least two prior treatments will receive the combination. The goal is to see if the disease gets better or goes away.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Axatilimab (a drug given by IV) and Extracorporeal Photopheresis (a procedure that treats blood outside the body)
What this could lead to: If it works, this combination could offer a new treatment option for people with chronic graft-versus-host disease that hasn't responded to other therapies.
What could go wrong: This is a small, early-phase trial (Phase 2) with only 49 participants, so results may not apply to everyone. Side effects from the drug or procedure are possible, and the combination may not work better than existing treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Bronchiolitis Obliterans Syndrome chronic graft versus host disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CGVHD CHRONIC GRAFT VERSUS HOST DISEASE

Contacts and locations

Locations

Ann & Robert H. Lurie Children's Hospital of Chicago
RECRUITING

Chicago, Illinois, 60611, United States
University of California, San Francisco
RECRUITING

San Francisco, California, 94143, United States
University of Miami
RECRUITING

Miami, Florida, 33136, United States

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