New hope for GVHD patients who failed other treatments

NCT ID NCT04710576

Recruiting now Disease control Sponsor: Syndax Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a drug called axatilimab in people with chronic graft-versus-host disease (cGVHD), a complication after a stem cell transplant where donor cells attack the patient's body. Participants must have tried at least two other treatments without success. The goal is to see if axatilimab can reduce symptoms and improve quality of life, but lifelong immune-suppressing medication may still be needed.

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Conditions

The condition(s) this trial relates to.

Bronchiolitis Obliterans Syndrome chronic graft versus host disease graft versus host disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC GRAFT VERSUS HOST DISEASE

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AOU Citta della Salute e della Scienza di Torino - Ospedale Regina Margherita
COMPLETED

Torino, Italy
ASST degli Spedali Civili di Brescia
ACTIVE_NOT_RECRUITING

Brescia, Italy
ASST di Monza-Ospedale San Gerardo
COMPLETED

Monza, Italy
AZ Delta
ACTIVE_NOT_RECRUITING

Roeselare, Belgium
AdventHealth Orlando
COMPLETED

Orlando, Florida, 32806, United States
Barbara Ann Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States
Bristol Royal Hospital for Children
COMPLETED

Bristol, BS2 8BJ, United Kingdom
CHRU de Lille - Hopital Claude Huriez
COMPLETED

Lille, Hauts-de-France, 59037, France
CHRU de Nancy - Hôpitaux de Brabois
COMPLETED

Nancy, France
CHU Amiens Picardie - Hopital Sud
COMPLETED

Amiens, Hauts-de-France, 80054, France
CHU Bordeaux - Hopital Haut-Leveque - Centre François Magendie
ACTIVE_NOT_RECRUITING

Pessac, France
CHU Sainte-Justine
ACTIVE_NOT_RECRUITING

Montreal, Quebec, H3T 1C5, Canada
CHU de Grenoble
COMPLETED

La Tronche, Auvergne-Rhône-Alpes, 38700, France
CHU de Nantes - Hôtel-Dieu
COMPLETED

Nantes, France
Chaim Sheba Medical Center
ACTIVE_NOT_RECRUITING

Ramat Gan, 5262160, Israel
Children's National Medical Center
ACTIVE_NOT_RECRUITING

Washington D.C., District of Columbia, 20010, United States
China Medical University Hospital
ACTIVE_NOT_RECRUITING

Taichung, 40447, Taiwan
Cincinnati Children's Hospital Medical Center
COMPLETED

Cincinnati, Ohio, 45229, United States
Citta della Salute e della Scienza di Torino - Ospedale le Molinette
COMPLETED

Torino, Italy
City of Hope
ACTIVE_NOT_RECRUITING

Duarte, California, 91010, United States
Complejo Hospitalario Universitario de Granada - Hospital Universitario Virgen de las Nieves
ACTIVE_NOT_RECRUITING

Granada, 18014, Spain
Dana Farber Cancer Institute
ACTIVE_NOT_RECRUITING

Boston, Massachusetts, 02215, United States
Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico di Milano
COMPLETED

Milan, 20122, Italy
Fondazione IRCCS Policlinico San Matteo
COMPLETED

Pavia, 27100, Italy
Fondazione IRCCS Policlinico San Matteo
COMPLETED

Pavia, Italy
Fondazione Monza e Brianza per il Bambino e la sua Mamma
COMPLETED

Monza, Italy
Fondazione Policlinica Universitario A. Gemelli IRCCS - Universita Cattolica del Sacro Cuore
ACTIVE_NOT_RECRUITING

Roma, 168, Italy
Franciscan Health Indianapolis
COMPLETED

Indianapolis, Indiana, 46237, United States
Fred Hutchinson Cancer Research Center
RECRUITING

Seattle, Washington, 98109, United States
Froedtert Hospital and the Medical College of Wisconsin
ACTIVE_NOT_RECRUITING

Milwaukee, Wisconsin, 53226, United States
General Hospital of Thessaloniki G. Papanikolaou - Hematology Department, BMT Unit
ACTIVE_NOT_RECRUITING

Eksochi, Thessaloniki, 57010, Greece
HCL Centre Hospitalier Lyon Sud
ACTIVE_NOT_RECRUITING

Pierre-Bénite, France
Hadassah Medical Center Ein Karem
ACTIVE_NOT_RECRUITING

Jerusalem, 9112001, Israel
Hammersmith Hospital
ACTIVE_NOT_RECRUITING

London, United Kingdom
Henry Ford Hospital
COMPLETED

Detroit, Michigan, 48202, United States
Hopital Pitie Salpetriere
ACTIVE_NOT_RECRUITING

Paris, 75013, France
Hopital Saint Louis
COMPLETED

Paris, 75010, France
Hospital Clinic Barcelona
ACTIVE_NOT_RECRUITING

Barcelona, 8032, Spain
Hospital Clinico Universitario de Salamanca
ACTIVE_NOT_RECRUITING

Salamanca, 37007, Spain
Hospital Clinico Universitario de Valencia
COMPLETED

Valencia, 46010, Spain
Hospital General Universitario Gregorio Maranon
ACTIVE_NOT_RECRUITING

Madrid, 28007, Spain
Hospital Universitari i Politecnic La Fe
ACTIVE_NOT_RECRUITING

Valencia, 46026, Spain
Hospital Universitario Donostia
COMPLETED

Donostia / San Sebastian, Spain
Hospital Universitario La Paz
COMPLETED

Madrid, 28046, Spain
Hospital Universitario Marquis de Valdecilla
ACTIVE_NOT_RECRUITING

Santander, Spain
Hospital Universitario Puerta de Hierro
ACTIVE_NOT_RECRUITING

Majadahonda, Spain
Hospital Universitario Ramon y Cajal
COMPLETED

Madrid, 28034, Spain
Hospital Universitario Vall d'Hebron
ACTIVE_NOT_RECRUITING

Barcelona, 08035, Spain
Hospital Universitario Virgen del Rocio
ACTIVE_NOT_RECRUITING

Seville, Seville, 41013, Spain
IRCCS Ospedale San Raffaele
ACTIVE_NOT_RECRUITING

Milan, 20132, Italy
IUCT-Oncopole
COMPLETED

Toulouse, Haure-Garrone, 31100, France
Indiana University Health Melvin and Bren Simon Cancer Center
ACTIVE_NOT_RECRUITING

Indianapolis, Indiana, 46202, United States
Institut de cancérologie Strasbourg Europe (ICANS)
ACTIVE_NOT_RECRUITING

Strasbourg, Grand Est, 67200, France
Instituto Portugues de Oncologia de Lisboa Francisco Gentil, E.P.E. (IPO-Lisboa)
COMPLETED

Lisbon, 1099-023, Portugal
Instituto Portugues de Oncologia do Porto Francisco Gentil, EPE
COMPLETED

Porto, Portugal
Intermountain Healthcare
RECRUITING

Salt Lake City, Utah, 84111, United States
Johns Hopkins Kimmel Cancer Center
COMPLETED

Baltimore, Maryland, 21231-2410, United States
KK Women's and Children hospital
COMPLETED

Singapore, 229899, Singapore
Kaohsiung Medical University Chung-Ho Memorial Hospital
COMPLETED

Kaohsiung City, 80756, Taiwan
King's College Hospital NHS Foundation Trust
ACTIVE_NOT_RECRUITING

London, United Kingdom
Korea University Anam Hospital
COMPLETED

Seoul, South Korea
MD Anderson Cancer Center
ACTIVE_NOT_RECRUITING

Houston, Texas, 77030, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic - Jacksonville
ACTIVE_NOT_RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic - Rochester
ACTIVE_NOT_RECRUITING

Rochester, Minnesota, 55905, United States
McGill University Health Center - Research Institute
ACTIVE_NOT_RECRUITING

Montreal, Quebec, H3G 1A4, Canada
Moffitt
ACTIVE_NOT_RECRUITING

Tampa, Florida, 33612, United States
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy, Oddzial w Gliwicach - Klinika Transplantacji Szpiku i Onkohematologii
COMPLETED

Gliwice, 44-102, Poland
National Taiwan University Hospital
ACTIVE_NOT_RECRUITING

Taipei, 100, Taiwan
National University Hospital
ACTIVE_NOT_RECRUITING

Singapore, 119074, Singapore
Northside Hospital
ACTIVE_NOT_RECRUITING

Atlanta, Georgia, 30342, United States
Oregon Health & Science University
RECRUITING

Portland, Oregon, 97239, United States
Princess Margaret Hospital
COMPLETED

Toronto, Ontario, Canada
Pusan National University Hospital
ACTIVE_NOT_RECRUITING

Busan, South Korea
Queen Elizabeth University Hospital
COMPLETED

Glasgow, United Kingdom
Rambam Health Care Campus
ACTIVE_NOT_RECRUITING

Haifa, 3109601, Israel
Royal Marsden Foundation Trust
COMPLETED

London, United Kingdom
Rutgers Cancer Institute of New Jersey
ACTIVE_NOT_RECRUITING

New Brunswick, New Jersey, 08903, United States
Seoul National University Hospital
ACTIVE_NOT_RECRUITING

Seoul, South Korea
Severance Hospital
COMPLETED

Seoul, South Korea
Singapore General Hospital
COMPLETED

Singapore, Singapore
Stanford Cancer Center
ACTIVE_NOT_RECRUITING

Stanford, California, 94305, United States
Stony Brook University Medical Center
ACTIVE_NOT_RECRUITING

Stony Brook, New York, 11794, United States
Tel Aviv Sourasky Medical Center
ACTIVE_NOT_RECRUITING

Tel Aviv, 6423906, Israel
The Cleveland Clinic Foundation
ACTIVE_NOT_RECRUITING

Lyndhurst, Ohio, 44195, United States
The Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
The Royal Children's Hospital
COMPLETED

Parkville, Victoria, 3052, Australia
The University of Chicago Medical Center (UCMC)
RECRUITING

Chicago, Illinois, 60637, United States
Tulane University Medical Center
COMPLETED

New Orleans, Louisiana, 70112, United States
Universitaetsklinikum Carl Gustav Carus Dresden
COMPLETED

Dresden, 01307, Germany
Universitaetsklinikum Jena
COMPLETED

Jena, 07740, Germany
Universitaetsklinikum Leipzig
COMPLETED

Leipzig, 04103, Germany
Universitaetsklinikum Muenster
ACTIVE_NOT_RECRUITING

Münster, 48149, Germany
Universitaetsmedizin der Johannes Gutenberg - Universitaet Mainz
COMPLETED

Mainz, 55131, Germany
Universitaire Ziekenhuizen Leuven
ACTIVE_NOT_RECRUITING

Leuven, Belgium
Universitatsklinikum Regensburg
ACTIVE_NOT_RECRUITING

Regensburg, 93053, Germany
University General Hospital of Patras
COMPLETED

Pátrai, 26500, Greece
University Hospital of Wales
ACTIVE_NOT_RECRUITING

Cardiff, United Kingdom
University Hospital of West Attica - Attikon - Hematology Division
ACTIVE_NOT_RECRUITING

Athens, Greece
University Hospitals Cleveland Medical Center
COMPLETED

Cleveland, Ohio, 44106, United States
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35294, United States
University of Alabama at Birmingham - Children's of Alabama
COMPLETED

Birmingham, Alabama, 35233, United States
University of California, Los Angeles (UCLA) - Medical Center
COMPLETED

Los Angeles, California, 90059, United States
University of Florida (UF)
COMPLETED

Gainesville, Florida, 32610, United States
University of Massachusetts Memorial Medical Center
ACTIVE_NOT_RECRUITING

Worcester, Massachusetts, 01655, United States
University of Miami
RECRUITING

Miami, Florida, 33136, United States
University of Michigan
ACTIVE_NOT_RECRUITING

Ann Arbor, Michigan, 48084, United States
University of Minnesota
COMPLETED

Minneapolis, Minnesota, 55455, United States
University of Oklahoma - Health Sciences Center
ACTIVE_NOT_RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Pittsburgh Medical Center - Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
University of Southern California Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States
University of Utah
ACTIVE_NOT_RECRUITING

Salt Lake City, Utah, 84112, United States
University of Virginia Medical Center
COMPLETED

Charlottesville, Virginia, 22908, United States
University of Wisconsin - Carbone Cancer Center
ACTIVE_NOT_RECRUITING

Madison, Wisconsin, 53792, United States
Vancouver Coastal Health Authority
ACTIVE_NOT_RECRUITING

Vancouver, British Columbia, V5Z 1M9, Canada
Vanderbilt University Medical Center
ACTIVE_NOT_RECRUITING

Nashville, Tennessee, 37232, United States
Wake Forest
COMPLETED

Winston-Salem, North Carolina, 27157, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
Weill Medical College of Cornell University
ACTIVE_NOT_RECRUITING

New York, New York, 10022, United States
Westmead Hospital
COMPLETED

Westmead, Australia

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