Dental cleaning may ward off deadly transplant complication

NCT ID NCT07535008

Recruiting now Prevention Sponsor: Fred Hutchinson Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 4 times

Summary

This study tests whether a dental cleaning shortly after a stem cell transplant can prevent chronic graft-versus-host disease (GVHD), a common and serious complication. Researchers will enroll 45 adults receiving a donor stem cell transplant for blood cancer. The goal is to see if removing bacteria from dental plaque can reduce the risk of chronic GVHD.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dental cleaning
What this could lead to: If it works, this simple procedure could reduce the risk of chronic GVHD, a serious complication after stem cell transplant.
What could go wrong: This is a small, early feasibility study with only 45 participants, so results may not apply broadly. The link between dental plaque and GVHD is still uncertain.

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Conditions

The condition(s) this trial relates to.

acute graft versus host disease Bronchiolitis Obliterans Syndrome hematopoietic and lymphoid system neoplasm chronic graft versus host disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE GRAFT VERSUS HOST DISEASE CHRONIC GRAFT VERSUS HOST DISEASE HEMATOPOIETIC AND LYMPHATIC SYSTEM NEOPLASM

Contacts and locations

Locations

Fred Hutch/University of Washington Cancer Consortium
RECRUITING

Seattle, Washington, 98109, United States

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