Breast cancer breakthrough: fewer drugs after surgery may be enough for some patients

NCT ID NCT03716180

First seen Nov 01, 2025 · Last updated Jun 11, 2026 · Updated 35 times

Summary

This study tests a new approach for people with HER2-positive breast cancer. If the tumor disappears completely after a short course of chemotherapy and targeted drugs before surgery, patients may only need two antibody drugs after surgery instead of more chemotherapy. The goal is to see if this gentler plan works and is safe. About 100 adults with stage II or III breast cancer are taking part.

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Contacts and locations

Locations

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

  • DF/BWCC at Milford Regional Medical Center

    Milford, Massachusetts, 01757, United States

  • DF/BWCC in clinical affiliation with South Shore Hospital

    South Weymouth, Massachusetts, 02190, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

Conditions

Explore the condition pages connected to this study.