Diabetes drug metformin tested to halt blood cancer before it starts
NCT ID NCT04850846
First seen Sep 30, 2025 · Last updated Jun 15, 2026 · Updated 32 times
Summary
This study tests whether metformin, a widely used diabetes medicine, can prevent two pre-cancer conditions (MGUS and smoldering myeloma) from turning into active multiple myeloma. About 60 adults with higher-risk MGUS or low-risk smoldering myeloma will receive either metformin or a placebo pill for several months. Researchers will track changes in blood protein levels and other markers to see if metformin can slow or stop disease progression.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
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DF/ BWCC in Clinical Affiliation with South Shore Hospital
Weymouth, Massachusetts, 02190, United States
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Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Dana-Farber at Brighton
Brighton, Massachusetts, 02135, United States
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Dana-Farber at Merrimack Valley
Methuen, Massachusetts, 01844, United States
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Dana-Farber at Milford
Milford, Massachusetts, 01757, United States
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Dana-Farber at NHOH
Londonderry, New Hampshire, 35053, United States
Conditions
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