New leukemia drug may allow fewer hospital visits for kids

NCT ID NCT01574274

First seen Feb 05, 2026 · Last updated Jun 14, 2026 · Updated 17 times

Summary

This study tests a new form of chemotherapy called calaspargase pegol (SC-PEG) given every 3 weeks, compared to the standard Oncaspar given every 2 weeks, in 240 children and teens with acute lymphoblastic leukemia or lymphoma. The goal is to see if the new drug has similar side effects and drug levels while allowing fewer doses. The study also looks at whether adjusting treatment based on minimal residual disease (low levels of cancer cells) can improve cure rates, and whether giving antibiotics early can prevent serious infections.

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Contacts and locations

Locations

  • Centre Hospitalier U. de Quebec

    Québec, Quebec, Canada

  • Children's Hospital Boston

    Boston, Massachusetts, 02215, United States

  • Columbia University Medical Center, Morgan Stanley Children's Hospital of New York-Presbyterian

    New York, New York, 10032, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Hasbro Children's Hospital

    Providence, Rhode Island, 02903, United States

  • Hospital Sainte Justine, University of Montreal

    Montreal, Quebec, Canada

  • McMaster University

    Hamilton, Ontario, Canada

  • Montefiore Medical Center

    New York, New York, 10467, United States

Conditions

Explore the condition pages connected to this study.