New drug combo targets Hard-to-Treat prostate cancer

NCT ID NCT04846478

First seen May 18, 2026 · Last updated Jun 13, 2026 · Updated 4 times

Summary

This early-stage trial is testing whether two oral targeted drugs, talazoparib and tazemetostat, can be safely combined to treat metastatic castration-resistant prostate cancer. About 35 participants with advanced disease will receive the combination to see if it shrinks tumors or slows cancer growth. The main goals are to find the safest dose and check for side effects.

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Contacts and locations

Locations

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

Conditions

Explore the condition pages connected to this study.