Immunotherapy duo targets rare, Mutation-Rich breast cancer

NCT ID NCT03789110

Ongoing Disease control Sponsor: Dana-Farber Cancer Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a combination of two immunotherapy drugs, nivolumab and ipilimumab, in 30 people with a rare, advanced form of HER2-negative breast cancer that has many genetic mutations (hypermutated). The goal was to see if this drug pair could shrink or control the cancer. Participants received the drugs intravenously, and the study measured how many people's tumors responded to treatment.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm Her2-receptor negative breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

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Locations

Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15213, United States
University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States