New drug duo shows promise for hard-to-treat blood cancers

NCT ID NCT03534323

First seen Mar 29, 2026 · Last updated May 14, 2026 · Updated 10 times

Summary

This study tests a combination of two oral drugs, duvelisib and venetoclax, in 55 adults with relapsed or refractory chronic lymphocytic leukemia (CLL) or Richter's Syndrome. The goal is to see how well the drugs work together to shrink or control the cancer. Participants must have tried at least one prior therapy. The study is active but no longer recruiting.

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Contacts and locations

Locations

  • Berkshire Medical Center

    Pittsfield, Massachusetts, 01201, United States

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

  • Boston Medical Center

    Boston, Massachusetts, 02118, United States

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Northern Light Eastern Maine Medical Center

    Brewer, Maine, 04412, United States

  • University of Miami- Sylvester Comprehensive Cancer Center

    Miami, Florida, 33136, United States

Conditions

Explore the condition pages connected to this study.