RICHTER SYNDROME
Clinical trials for RICHTER SYNDROME explained in plain language.
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New drug combo targets aggressive lymphoma in CLL patients
Disease control Recruiting nowThis study tests a new drug called glofitamab, given with standard chemotherapy, for people with untreated Richter syndrome (an aggressive lymphoma that develops from chronic lymphocytic leukemia). The goal is to see if this combination can shrink or eliminate the cancer. About 4…
Matched conditions: RICHTER SYNDROME
Phase: PHASE2 • Sponsor: French Innovative Leukemia Organisation • Aim: Disease control
Last updated Jul 02, 2026 00:00 UTC
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New drug duo takes on rare, deadly lymphoma
Disease control Recruiting nowThis phase II trial tests whether combining nemtabrutinib (a targeted drug) with pembrolizumab (an immunotherapy) can shrink tumors in 32 people with Richter transformation, an aggressive lymphoma that arises from chronic lymphocytic leukemia. Participants must have failed or be …
Matched conditions: RICHTER SYNDROME
Phase: PHASE2 • Sponsor: Roswell Park Cancer Institute • Aim: Disease control
Last updated Jun 27, 2026 12:35 UTC
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New combo therapy aims to keep lymphoma at bay after transplant
Disease control Recruiting nowThis study is testing whether a drug called polatuzumab vedotin can safely help control lymphoma after a stem cell transplant. About 20 people with B-cell or Hodgkin lymphoma who have had a relapse or not responded to prior treatment will receive the drug if their disease is stab…
Matched conditions: RICHTER SYNDROME
Phase: PHASE1, PHASE2 • Sponsor: New York Medical College • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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New hope for rare, aggressive blood cancer: 3-Drug cocktail targets richter transformation
Disease control Recruiting nowThis study tests a combination of three drugs (acalabrutinib, venetoclax, and durvalumab) in people with Richter transformation, a rare and fast-growing lymphoma that develops from chronic lymphocytic leukemia (CLL). The goal is to control the disease and improve survival. About …
Matched conditions: RICHTER SYNDROME
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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Promising new combo tackles rare leukemia complication
Disease control Recruiting nowThis phase 2 trial is testing whether adding the drug polatuzumab vedotin to standard chemotherapy can improve remission rates in people with Richter's transformation, an aggressive lymphoma that can develop from chronic lymphocytic leukemia (CLL). About 20 adults with confirmed …
Matched conditions: RICHTER SYNDROME
Phase: PHASE2 • Sponsor: Weill Medical College of Cornell University • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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Experimental combo targets Hard-to-Treat blood cancer
Disease control Recruiting nowThis early-phase trial is testing whether combining two drugs—zanubrutinib and odronextamab—is safe for people with Richter's transformation, a rare and aggressive form of blood cancer that arises from chronic lymphocytic leukemia. The study will enroll 23 adults and monitor for …
Matched conditions: RICHTER SYNDROME
Phase: PHASE1 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Jun 26, 2026 17:45 UTC