Double-Drug attack on lung cancer: can two targeted pills work better than one?

NCT ID NCT03122717

First seen Nov 12, 2025 · Last updated May 01, 2026 · Updated 24 times

Summary

This study tests whether combining two targeted drugs, osimertinib and gefitinib, is safe and doable for people with advanced EGFR-mutant lung cancer. About 48 adults with stage IV non-small cell lung cancer that has not been treated with EGFR inhibitors before will take both pills daily for up to 6 months. The main goal is to see how many can stay on the combo without stopping due to side effects.

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Contacts and locations

Locations

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

Conditions

Explore the condition pages connected to this study.