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HER2+ breast cancer patients may finally get a treatment holiday

NCT ID NCT05721248

Ongoing Disease control Sponsor: Dana-Farber Cancer Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether people with HER2-positive metastatic breast cancer who have had their cancer controlled for at least three years can safely stop their anti-HER2 therapy. About 82 participants will either stop or continue treatment to see if the cancer stays away for a year. The goal is to reduce side effects and treatment burden without harming outcomes.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm HER2 positive breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER HER2-POSITIVE BREAST CANCER METASTATIC BREAST CANCER

Contacts and locations

Locations

  • Baylor College of Medicine

    Houston, Texas, 77030, United States

  • DFCI @ Foxborough

    Foxborough, Massachusetts, 02035, United States

  • DFCI @ Merrimack Valley

    Methuen, Massachusetts, 01844, United States

  • DFCI @ Milford Regional Hospital

    Milford, Massachusetts, 01757, United States

  • DFCI @ South Shore Hospital

    South Weymouth, Massachusetts, 02190, United States

  • Dana-Farber Cancer Insitute

    Boston, Massachusetts, 02215, United States

  • Duke University

    Durham, North Carolina, 27710, United States

  • Fred Hutchinson Cancer Center

    Seattle, Washington, 98109, United States

  • Georgetown University Medical Center

    Washington D.C., District of Columbia, 02809, United States

  • Mayo Clinic Hospital Arizona

    Phoenix, Arizona, 85054, United States

  • Mayo Clinic Rochester

    Rochester, Minnesota, 55905, United States

  • Mayo Clinical Hospital Florida

    Jacksonville, Florida, 32224, United States

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania, 15213, United States

More trials for these conditions

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