Experimental combo targets Hard-to-Treat head and neck cancers
NCT ID NCT03381183
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tested a combination of two drugs — IRX-2 and durvalumab — in 19 people with advanced head and neck cancer that could not be cured by standard treatments. The goal was to see if the combination was safe and could boost the immune response inside tumors. The study focused on finding the right dose and checking for side effects, not on curing the cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- IRX-2 regimen (cyclophosphamide and IRX-2) and durvalumab
- What this could lead to
- If successful, this combination could offer a new treatment option for people with advanced head and neck cancer that cannot be cured.
- What could go wrong
- This is a very early, small phase 1 trial with only 19 participants. The main goal is safety, not effectiveness. The treatment may not shrink tumors or improve survival, and side effects are unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
H. Lee Moffitt Cancer Center and Research Institute
Tampa, Florida, 33612, United States
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