H. Lee Moffitt Cancer Center And Research Institute

This study is testing whether combining two drugs, ACR-368 and a low dose of gemcitabine, can help control advanced head and neck cancer that has returned or spread. It will involve 43 patients who have already tried standard immunotherapy. Participants will receive the drug comb…

This early-stage trial is testing whether specially modified immune cells, taken from a patient's own tumor, can help fight advanced lung cancer when given alongside the drug nivolumab. The study is for adults with specific genetic changes in their lung cancer who have already tr…

This early-stage study aims to find the safest and most effective dose when combining two chemotherapy drugs, CPX-351 and gemtuzumab ozogamicin, to treat newly diagnosed acute myeloid leukemia (AML). Researchers will enroll up to 18 adult patients to test different dose levels an…

This study is testing whether giving immunotherapy drugs before surgery can lead to better outcomes for people with advanced melanoma that has spread to nearby lymph nodes or tissue. The treatment aims to help the patient's own immune system attack the cancer to shrink tumors pri…

This early-stage study is testing if adding aspirin to standard chemotherapy helps the body's immune system better fight ovarian, fallopian tube, or peritoneal cancer. It will involve 100 adults who are scheduled for chemotherapy before surgery. Researchers will measure changes i…

This study is testing whether a cancer vaccine called Sipuleucel-T works better when patients continue taking their standard hormone therapy drugs. It's for men with advanced prostate cancer that has spread but isn't causing major symptoms, and whose PSA levels are rising despite…

This study is testing whether a combination of two drugs, dostarlimab and niraparib, can help control advanced penile cancer that has continued to grow after standard chemotherapy. It will involve about 25 men with this specific type of cancer. The main goal is to see if the trea…

This early-stage trial is testing a new schedule of chemotherapy drugs for patients with widely spread Ewing's sarcoma, a rare bone and soft tissue cancer. The approach uses an initial strong treatment to shrink the main tumor, followed by a series of follow-up treatments and lon…

This study is testing whether KTE-X19, a type of CAR T-cell therapy, can help adults with B-cell acute lymphoblastic leukemia who are in remission but still have tiny amounts of cancer cells detectable in their bone marrow. The treatment involves collecting and genetically modify…

This study is testing whether a smartphone app that uses augmented reality (AR) can help people quit smoking when used alongside standard telephone counseling. Researchers will enroll 3,600 adult daily smokers to see if the app, which is designed to help manage cravings, improves…

This study compares four different dosing schedules of the drug vismodegib for people with advanced basal cell carcinoma, a type of skin cancer. Researchers want to see if personalized, on-and-off dosing schedules work better and are more tolerable than standard continuous or fix…

This early-phase study is testing the safety and best dose of a two-drug combination (Vyxeos and gilteritinib) for adults with a specific type of acute myeloid leukemia (AML) that has a FLT3 mutation and has returned or not responded to prior treatment. The goal is to see if this…

This study is testing whether adding a drug called venetoclax to a standard chemotherapy combination works better for adults with acute myeloid leukemia (AML) that has returned or not responded to prior treatment. Researchers want to see if this approach helps clear more cancer c…

This study is testing whether combining two existing drugs, axitinib and ipilimumab, can help control advanced melanoma in patients whose cancer didn't respond to previous immunotherapy. The trial will enroll 25 adults with advanced melanoma who have already tried anti-PD-1/PD-L1…

This study is testing whether adding a personalized vaccine to standard chemotherapy and targeted drugs can better treat HER2-positive breast cancer before surgery. The vaccine is made from the patient's own immune cells and aims to train the body to attack the cancer. Researcher…

This study is testing a combination of three immunotherapy drugs (Interleukin-2, ipilimumab, and nivolumab) for people with advanced, inoperable melanoma that has continued to grow despite prior immunotherapy. The goal is to see if this specific sequence and combination can bette…

This study is testing a two-step treatment for patients with large B-cell lymphoma that has come back or hasn't responded to other treatments. First, patients receive targeted radiation to all visible cancer sites to shrink large tumors. Then, they receive a personalized immune c…

This early-stage trial is testing a personalized cell therapy for people with advanced melanoma that hasn't responded to standard treatments. Doctors take immune cells from a patient's own tumor, boost them in the lab with a protein called CD40L, and then infuse them back into th…

This study is testing whether adding a pill called pirtobrutinib to a cell-based therapy (CAR T) works better for people with mantle cell lymphoma that has come back or stopped responding to treatment. The trial will enroll 60 adults to see if the combination helps patients live …

This study is testing a two-step treatment for people with a rare and aggressive eye cancer (uveal melanoma) that has spread mainly to the liver. First, doctors use a procedure to deliver high-dose chemotherapy directly to the liver. The goal is to damage the tumors and potential…

This study is testing whether the drug enfortumab vedotin can help control advanced colorectal cancer or liver cancer that has spread or cannot be surgically removed. It is for adults whose cancer has continued to grow despite trying standard treatments. The main goal is to see i…

This study is testing a new combination of four drugs for people with advanced stomach or esophageal cancer that has a specific genetic feature called HER2. The goal is to see if adding the drug neratinib to standard chemotherapy and two other targeted drugs is safe and can bette…

This study is testing whether adding a targeted drug (sacituzumab govitecan) and an immunotherapy drug (zimberelimab) to precise brain radiation works better and is safe for people with triple negative breast cancer that has spread to the brain. It will involve about 31 participa…

This study is testing whether a combination of two drugs (tafasitamab and lenalidomide) can help people with large B-cell lymphoma who still have cancer after receiving CAR-T cell therapy. The research aims to see if this treatment is safe and effective at eliminating or reducing…

This study is testing an immunotherapy drug called pembrolizumab for adults with advanced cutaneous sarcoma, a rare type of skin cancer. The goal is to see if the drug can shrink tumors and help control the disease. About 17 participants will receive the drug through an IV every …

This study is testing a new strategy for treating advanced breast cancer that has spread. Researchers want to see if giving a specific sequence of already-approved drugs is practical and might work better than current approaches. The study will involve 15 women with a specific ty…

This early-stage study is testing the safety of a new treatment for ovarian cancer that has returned after previous therapies. Doctors take a patient's own immune cells (T cells), modify them in a lab to better recognize cancer, and then infuse them back into the body. The main g…

This study is testing a new way to plan radiation treatment for high-grade soft tissue sarcoma before surgery. Researchers are using special imaging analysis to find the toughest parts of the tumor and target them with higher doses of radiation. The goal is to kill more of the ca…

This study is testing whether an automated text messaging program can help people living with HIV in Cambodia quit smoking. It will enroll 800 adult smokers with HIV who are willing to try to quit. Researchers will check if participants have quit by asking them and using a breath…

This study is testing whether adding a drug called abemaciclib to precise radiation therapy can better control breast cancer that has spread to the brain. It will involve about 31 patients whose breast cancer is hormone-sensitive and has formed a limited number of brain tumors. T…

This early-stage study is testing the safety of a new combination treatment for people with metastatic HER2-positive breast cancer. It uses a personalized vaccine to train the immune system, followed by an infusion of specially grown immune cells, alongside standard medications. …

This is an early safety study testing a new two-part treatment for advanced breast cancer that has spread. It combines a personalized vaccine made from a patient's own immune cells with a hormone-blocking pill. The goal is to see if this combination is safe and feasible for patie…

This early-stage study is testing the safety of combining two drugs, avapritinib and decitabine, for patients with a rare and complex blood cancer called SM-AHN. The goal is to find a dose that is safe and tolerable while trying to control both the mast cell and the blood cell pa…

This study is testing if digoxin, a medication commonly used for heart conditions, can help control a rare and aggressive brain cancer called medulloblastoma when it has come back after initial treatment. It will involve about 23 children and young adults (ages 1-30) whose cancer…

This study is testing whether giving two drugs, cetuximab and cemiplimab, before surgery can help people with head and neck cancer. The goal is to see if this combination can shrink or even eliminate the tumor, which might lead to better long-term results. The trial will enroll 2…

This study aims to find the better first treatment for chronic graft-versus-host disease (cGVHD), a serious complication that can occur after a bone marrow transplant. Researchers will compare two drugs—ruxolitinib (already approved for later treatment) and prednisone (current st…

This study is testing how well the immunotherapy drug pembrolizumab, with or without chemotherapy, works for Black patients with advanced non-small cell lung cancer. It aims to see how long patients live and how long the cancer stays controlled, while also looking for markers in …

This study is testing a two-step treatment for advanced prostate cancer that has become resistant to standard hormone therapy. First, men receive high-dose testosterone, followed by a targeted radiation drug that seeks out and destroys cancer cells. The goal is to see if this com…

This early-stage study is testing a new type of personalized vaccine, made from a patient's own immune cells, given directly into the tumor along with standard chemotherapy. It aims to see if this combination is safe and can help shrink tumors in people with aggressive forms of b…

This study is testing a combination of two existing drugs, olaparib and pembrolizumab, to see if they can work together to control advanced uveal melanoma, a rare and aggressive cancer that starts in the eye. It will involve about 37 adults whose cancer has spread. The main goal …

This study is testing whether radiation therapy followed by targeted cancer drugs delivered directly into the spinal fluid is safe and effective for treating HER2-positive breast cancer that has spread to the lining of the brain and spinal cord. The trial will involve 39 patients…

This study is testing whether the drug luspatercept can help adults with anemia from certain lower-risk bone marrow disorders become less dependent on regular blood transfusions. Researchers will enroll about 70 participants who currently need frequent transfusions and see if add…

This study is testing whether genetic information from a patient's tumor can help doctors personalize radiation doses after breast cancer surgery. Researchers want to see if this approach improves cancer control while maintaining quality of life. The trial includes 86 people with…

This study is testing whether the drug afatinib can help control advanced skin cancer that can't be treated with surgery or radiation. It's for people whose cancer has continued to grow despite trying immunotherapy. Researchers will measure if tumors shrink, how long the cancer s…

This study is testing whether combining two existing drugs—rituximab and zanubrutinib—is safe and effective for people with untreated slow-growing B-cell lymphomas. It will enroll 43 adults with either follicular lymphoma or marginal zone lymphoma who need systemic treatment. Res…

This study is testing if a combination of two drugs, cemiplimab and Ziv-aflibercept, can help control metastatic uveal melanoma, a rare cancer that starts in the eye and spreads. The main goal is to see if the treatment can shrink tumors or stop them from growing. It will involve…

This early-stage trial is testing a personalized vaccine for people with high-risk triple-negative breast cancer who still have cancer cells after standard chemotherapy and surgery. Doctors create a custom vaccine from the patient's own tumor and immune cells, aiming to train the…

This study is testing whether eating more fermented foods like yogurt, kimchi, and kombucha can help people with rectal or lung cancer. Researchers want to see if this special diet makes standard cancer treatments like chemotherapy and immunotherapy work better. They will also ch…

This study tests whether adding the drug elranatamab as maintenance therapy after CAR-T cell treatment can help keep myeloma from returning in high-risk patients. It will measure how long patients live without their cancer getting worse. The trial is for people with relapsed myel…

This early-stage trial is testing a new type of immune cell therapy for men with advanced prostate cancer that has spread to bones and no longer responds to standard hormone treatments. Doctors will collect patients' own immune cells, modify them in a lab to better target prostat…

This study is testing if taking a daily pill called itacitinib for about a month before receiving a specialized cell therapy (CAR-T) can improve results for adults with an aggressive type of lymphoma. The researchers want to see if this approach helps control the cancer longer an…

This study is testing if a drug called asciminib is safe and can help prevent a serious type of leukemia from returning in adults. It's for people who are in remission after receiving either a stem cell transplant or CAR T-cell therapy. The main goals are to find a safe dose and …

This is a first-in-human safety study testing a new immune-boosting vaccine for breast cancer that has spread to the membranes surrounding the brain and spinal cord. Researchers will give the vaccine directly into the spinal fluid of up to 18 patients to find the highest dose tha…

This early-stage study is testing whether adding a new drug called calaspargase pegol to standard chemotherapy is safe for young adults newly diagnosed with acute lymphoblastic leukemia. Researchers will monitor 7 participants closely for side effects and early signs of how well …

This study tests whether treatment decisions for advanced melanoma can be personalized based on how well tumors respond to drug therapy before surgery. Patients with specific genetic mutations receive targeted drugs before surgery, then get different follow-up treatments dependin…

This study is testing whether adults with newly diagnosed acute myeloid leukemia (AML) who have achieved deep remission can safely stop their chemotherapy for a period after one year of treatment. Researchers want to see if taking a break from treatment reduces side effects while…

This early-stage study is testing a medication called ropeginterferon for people with advanced cutaneous T-cell lymphoma (CTCL), a type of skin cancer. The main goals are to find the safest and most effective dose and to see how well the drug works in patients whose disease hasn'…

This study aims to improve lung cancer care by testing whether specific biomarkers in blood and tissue can better diagnose lung nodules, identify patients at high risk of cancer returning after surgery, and detect late recurrence. Researchers will follow 250 adults with suspiciou…

This study aims to develop better tools to predict which pancreatic cysts might turn into cancer. Researchers will collect medical scans, blood samples, and health information from over 1,100 people with pancreatic cysts or tumors. By analyzing this data, they hope to create non-…

This study is testing a new oral swab that looks for specific markers linked to HPV-related throat cancer. The goal is to see if this simple test can accurately find cancer early, when treatment is often more successful. Researchers will compare results from 200 people with throa…

This study is testing a new type of imaging scan called PSMA-PET to see if it can better detect prostate cancer that has returned or spread in men who are at high risk based on a genetic test. It will enroll 60 men who previously had high-risk genetic test results and were treate…

This study is testing a new Spanish-language program called ProSalud, which aims to teach Latino parents in rural Florida about healthy habits to lower their family's cancer risk. Parents attend a workshop about nutrition, exercise, and sun safety, and some are later asked for fe…

This study aims to see if different ways of telling people about their personal skin cancer risk can encourage them to adopt better sun safety habits. It will enroll 2,900 adults from community health centers who have recently tanned or gotten sunburned. Researchers will track ch…

This study is testing whether a remote exercise and nutrition program is practical and helpful for people preparing for pancreatic cancer surgery. Researchers want to see if patients can complete the program and if it improves their strength and recovery. The study will compare o…

This study is testing whether a remote support program can help pancreatic cancer patients maintain their weight and nutrition after surgery. The program provides extra access to a dietitian and uses a mobile app for food tracking. Researchers want to see if patients find it help…

This small pilot study is testing whether an exercise program before surgery is practical and acceptable for people with esophageal cancer. Researchers want to see if patients can complete the exercise program and if it might help with recovery after surgery. The study involves 2…

This study is testing whether following the MIND diet can help improve memory, focus, and thinking problems (often called 'chemo brain') in breast cancer survivors. It will involve 200 women who have finished their main cancer treatment but still report cognitive issues. Particip…

This study is testing if a guided, at-home strength training program is safe, practical, and helpful for people with advanced stomach or intestinal cancer who are undergoing chemotherapy. Researchers will enroll 100 participants to see if the program improves muscle strength, red…

This study is testing whether a remote support program can help people with stomach or esophageal cancer avoid malnutrition during treatment. Participants will use a phone app to track food and meet with a dietitian remotely, comparing this approach to usual care. The goal is to …

This study is testing whether a special team of doctors and scientists can create new, personalized treatment plans for people with incurable cancer. It will enroll 35 patients who have run out of standard curative options. The main goal is to see if this team can successfully de…

This study aims to find out if regular brain MRI scans can detect cancer that has spread to the brain in patients with advanced breast cancer who have no neurological symptoms. Researchers will enroll 170 patients with stage IV breast cancer to see how often these scans find hidd…

This study aims to understand how obesity might contribute to the development and progression of pancreatic cancer, particularly in African American adults. Researchers will observe and compare biological samples from about 125 adults who are African American or Non-Hispanic Whit…

This study aims to find out how often breast cancer spreads to other body parts after patients complete chemotherapy and surgery. Researchers will use CT scans to check 120 patients with node-positive breast cancer at the start and again 6 months later if the first scan is clear.…

This study is testing a new AI tool designed to spot a serious condition called cachexia (severe weight and muscle loss) early in people with pancreatic cancer. It also aims to see if personalized diet and exercise plans are practical and acceptable for patients to help manage th…

This study aims to understand how quality of life, fatigue, and symptoms change over two years for adults being treated for chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). Researchers will follow 100 participants receiving different treatment types to lear…

This study is testing new outreach and education strategies to increase enrollment of Black and Hispanic patients in cancer treatment trials at Moffitt Cancer Center. Researchers will work with community members, doctors, and patients using educational sessions, digital tools, an…

This study is testing a new approach to help children and young adults whose cancers are considered incurable or not responding well to standard treatments. A special team of doctors from different hospitals will review each patient's case to see if they can suggest new, personal…

This study aims to increase cancer awareness and encourage participation in cancer research through community education programs. Researchers will work with 1,200 adults in Florida and Puerto Rico, offering online training, workshops, and podcasts in both English and Spanish. The…