Brain scans every 6 months could catch cancer spread earlier in stage IV breast cancer

NCT ID NCT07357298

Recruiting now Diagnosis Sponsor: H. Lee Moffitt Cancer Center and Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase III trial is testing whether routine brain MRIs every 6 months can detect brain metastases earlier in people with stage IV breast cancer who have no symptoms. Participants are randomly assigned to either scheduled scans or standard care (scans only if symptoms appear). The goal is to see if earlier detection changes treatment options and improves outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Surveillance Brain MRI
What this could lead to: If successful, this could show that regular brain scans help catch metastases earlier, potentially reducing the need for whole-brain radiation and improving quality of life.
What could go wrong: This is a phase III trial, but it's still relatively small (156 participants) and focuses on detection, not a direct treatment. Earlier detection may not always improve survival or outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

Baptist Health South Florida
NOT_YET_RECRUITING

Miami, Florida, 33176, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States

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