Can two drugs together fight Hard-to-Treat bone and Soft-Tissue cancers?
NCT ID NCT07725380
First seen Jul 24, 2026 · Last updated Jul 24, 2026
Summary
This trial tests whether combining domatinostat with sirolimus can safely shrink or slow the growth of relapsed or refractory sarcoma and osteosarcoma in adolescents and adults aged 12 to 40. Participants must have already tried at least one standard therapy without success. The study first finds the best dose (phase 1) and then checks how well it works (phase 2).
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- domatinostat combined with sirolimus
- What this could lead to
- If it works, this combination could offer a new treatment option for people with sarcoma or osteosarcoma that has stopped responding to standard therapies.
- What could go wrong
- This is an early-phase trial with a small number of participants, so the combination may not prove effective or may cause significant side effects. Success in phase 1/2 does not guarantee broader benefit.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Moffitt Cancer Center
RECRUITINGTampa, Florida, 33612, United States
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Montefiore Medical Center
NOT_YET_RECRUITINGThe Bronx, New York, 10467, United States
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Nationwide Children's Hospital
NOT_YET_RECRUITINGColumbus, Ohio, 43205, United States
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Washington University in St. Louis
NOT_YET_RECRUITINGSt Louis, Missouri, 63110, United States
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