H. Lee Moffitt Cancer Center And Research Institute

This study tests the drug ruxolitinib (Jakafi) in 29 people with chronic myelomonocytic leukemia (CMML), a rare blood cancer. The goal is to see if the drug can improve blood counts, shrink the cancer, or delay its turning into a more aggressive leukemia. Researchers are also che…

This study tests whether adding the immune-boosting drug Sipuleucel-T (Provenge) to standard hormone therapy can help men with advanced prostate cancer that is no longer responding to hormones alone. The trial involves 26 participants who will receive either Sipuleucel-T alone or…

This phase II trial tests two drugs—olaparib and pembrolizumab—together in 12 people with advanced uveal melanoma, a rare eye cancer that has spread. The goal is to see if the combination can shrink tumors or slow the disease. The study is active but no longer recruiting, and res…

This early-phase study tests the safety of giving specially grown immune cells (T cells) to people with metastatic HER2-positive breast cancer. Participants first receive a vaccine made from their own immune cells plus two drugs (pepinemab and trastuzumab) to help the body fight …

This phase 2 trial is testing whether adding the drug neratinib to a standard combination of chemotherapy, trastuzumab, and pembrolizumab can shrink tumors in people with HER2-positive gastroesophageal cancers. The study includes 8 participants and aims to measure how many respon…

This study tests whether radiation therapy followed by injecting two targeted antibodies (trastuzumab and pertuzumab) directly into the spinal fluid is safe and improves survival for people with HER2+ breast cancer that has spread to the lining of the brain and spine. About 33 pa…

This study tests whether eating 3-6 servings of fermented foods daily (like yogurt, kefir, and sauerkraut) can improve how well cancer treatments work in patients with locally advanced rectal cancer or non-small cell lung cancer. The 39 participants are randomly assigned to eithe…

This study tests whether giving two drugs (cetuximab and cemiplimab) before surgery can help shrink tumors in people with head and neck squamous cell carcinoma. About 22 adults will receive the combination before their planned surgery. The main goal is to see how many patients ha…

This study tested whether adding stress management techniques to a standard weight loss program helps Black women with obesity lose more weight. Over 300 women with high stress levels took part. The goal was to see if a culturally-tailored approach could improve weight loss resul…

This early-phase study tests whether combining two cancer drugs—ceritinib and docetaxel—can safely help people with advanced non-small cell lung cancer that has not responded to other treatments. About 21 adults with stage IIIB or IV disease will receive the drugs to find the bes…

This early-phase trial tests a dendritic cell vaccine given directly into the spinal fluid for people with breast cancer that has spread to the lining of the brain (leptomeningeal disease). The vaccine is designed to train the immune system to attack cancer cells. The main goal i…

This study tests a drug called luspatercept in 6 adults with lower-risk myelodysplastic syndromes (MDS) or related blood cancers who have anemia. The goal is to see if the drug can reduce or eliminate the need for regular blood transfusions. Participants receive luspatercept plus…

This phase 2 trial is testing whether giving a combination of two drugs—lenvatinib and pembrolizumab—before surgery can help people with Merkel cell carcinoma. The study involves 26 participants with stage II, III, or IV disease. The main goal is to see if the treatment leads to …

This study tests whether combining two drugs, binimetinib and belinostat, can shrink or stop the growth of metastatic uveal melanoma, a rare eye cancer that has spread. About 7 adults with this condition are taking part. The main goal is to see how many patients respond to the tr…

This study is testing whether a combination of three drugs—nivolumab, ipilimumab, and nintedanib—can safely shrink tumors in people with advanced non-small cell lung cancer that has no curative options. The trial involves 66 participants and is split into two phases: the first fi…

This phase 2 trial tests whether adding ruxolitinib to a standard tyrosine kinase inhibitor (TKI) can help people with chronic myeloid leukemia (CML) stop their medication for longer. Participants had previously tried stopping a TKI but relapsed. The study enrolls 24 adults and m…

This study tests whether a daily dose of green tea catechins (a natural compound) can prevent low- to intermediate-risk prostate cancer from getting worse in men who are not receiving immediate treatment. Over 24 months, 115 men will receive either the green tea extract or a plac…

This early-phase trial tests whether adding chest radiation followed by immunotherapy drugs (durvalumab alone or with tremelimumab or olaparib) can help control extensive-stage small cell lung cancer after initial chemotherapy. About 25 adults whose cancer did not worsen after fi…

This study tests whether adding the immunotherapy drug nivolumab (Opdivo) to standard radiation and hormone therapy is safe and effective for men with a very aggressive form of prostate cancer (Gleason grade group 5). About 44 men will receive the drug combination. The goal is to…

This early-stage trial tests a treatment called CG0070, a virus-based therapy given directly into the bladder, after standard surgery for intermediate-risk non-muscle invasive bladder cancer. About 20 participants will receive the treatment to see if it is safe and helps prevent …

This study tests whether a program combining phone counseling and personalized text messages can help 360 cervical cancer survivors in Florida quit smoking better than standard quitline services. Participants must have a history of cervical cancer or high-grade cervical dysplasia…

This phase 2 trial is testing whether giving focused radiation before surgery for brain metastases can delay tumor regrowth better than standard care. About 49 adults with solid tumors (not lymphoma or germ cell) and at least one brain metastasis will receive three daily doses of…

This early-phase trial tests whether using MRI scans during radiation treatment can help doctors adjust the radiation dose to better target rectal cancer. Twenty people with stage II or III rectal cancer will receive standard chemotherapy plus MRI-guided radiation. The main goal …

This study tests a new approach for men with stage IV prostate cancer that still responds to hormone therapy. Instead of continuous hormone treatment, doctors adjust the timing based on PSA levels and add chemotherapy. The goal is to see if this strategy can keep the cancer sensi…

This study tests whether adding targeted radiation (SBRT) to the immunotherapy drug atezolizumab can shrink tumors better than atezolizumab alone in people with cervical cancer that has come back or spread. About 21 adults with advanced cervical cancer are participating. The goal…

This early-phase trial tests a new approach for advanced head and neck cancer that has stopped responding to standard treatments. Doctors take a patient's own tumor-fighting immune cells (TILs), grow more of them in a lab, and give them back along with the immunotherapy drug Keyt…

This study tests whether a 6-month program of exercise tracking and nutrition coaching is practical and acceptable for people with pancreatic cysts that raise cancer risk. Twenty-four participants will use a Fitbit and meet with counselors to increase activity and improve diet. T…

This Phase II study tests a treatment plan using daratumumab (Darzalex) and dexamethasone for adults aged 65 and older with newly diagnosed multiple myeloma who cannot handle intensive chemotherapy. The goal is to see how well the combination controls the disease by measuring res…

This study tests whether adding focused radiation to a two-drug immunotherapy combination works better than the drugs alone for people with advanced Merkel cell carcinoma, a rare and aggressive skin cancer. About 50 adults with cancer that has spread or cannot be removed will rec…

This early-phase study tests a combination of two drugs—romidepsin and durvalumab—given directly into the bladder for people with muscle-invasive bladder cancer who cannot receive standard chemotherapy. The goal is to see if the combination is safe and can shrink or eliminate tum…

This phase II trial tests whether adjusting doses of two drugs—pembrolizumab (Keytruda) and axitinib (Inlyta)—based on tumor response can better control advanced kidney cancer. The study aims to enroll 75 adults with clear cell renal cell carcinoma that has spread. The trial is c…

This phase 1/2 trial tests whether adding difluoromethylornithine (DFMO) to the immunotherapy pembrolizumab (Keytruda) is safe and effective for people with advanced non-small cell lung cancer that has a specific genetic change (STK11/LKB1 deficiency). About 45 participants will …

This early-phase trial tests a new three-drug combination for people with advanced BRAF-mutated melanoma that cannot be removed by surgery. The drugs are XL888 (an HSP90 inhibitor), vemurafenib, and cobimetinib. The main goal is to find the safest dose of XL888 when given with th…

This phase 2 trial tests whether a combination of curcumin (from turmeric) and fish oil can reduce the size of lung nodules in former and current smokers aged 55 and older. Nineteen participants took the supplements or a placebo for 6 months. The study aims to see if the nodules …

This pilot study tests whether combining a targeted drug (mogamulizumab) with ultraviolet light therapy (phototherapy) can better control early-stage mycosis fungoides, a type of skin lymphoma. Twenty adults with stage IA-IIA disease will receive the drug for 8 cycles and add pho…

This study tests whether a smartphone-based program can help people living with HIV quit smoking better than standard phone counseling. About 638 participants will use nicotine patches and lozenges along with either automated video coaching or traditional quitline support. The go…

This early-phase trial tests whether infusing specially grown donor immune cells (gamma delta T-cells) can prevent acute myeloid leukemia from returning in patients who are at high risk of relapse after a stem cell transplant. About 20 adults aged 18–75 will receive a single infu…

This early-phase study tests whether 30 minutes of moderate exercise (like walking or cycling) right before standard immunotherapy can improve treatment for certain skin cancers (melanoma, squamous cell carcinoma, Merkel cell carcinoma). About 22 adults will exercise before each …

This early-phase study tested a new way of giving three drugs (encorafenib, binimetinib, and nivolumab) to people with advanced BRAF-mutant melanoma. Instead of taking the drugs every day, participants followed an on/off schedule to see if it could control the cancer while reduci…

This early-phase trial tests the safety and effectiveness of the immune drug nivolumab (Opdivo) alone or combined with the chemo drug azacitidine (Vidaza) in people whose osteosarcoma has come back and can be surgically removed. About 21 participants will receive the drugs before…

This study looks at whether giving a pneumonia vaccine (PCV13) before and after CAR T-cell therapy helps lymphoma patients build stronger immunity. About 26 adults with certain types of B-cell lymphoma will receive the vaccine around their CAR T treatment. The goal is to see if t…

This study tests whether combining two drugs, pembrolizumab and vorinostat, can help control advanced non-small cell lung cancer. About 120 adults with stage IV lung cancer will receive either the combination or pembrolizumab alone. The goal is to see if the combination is safe a…

This study tests a combination of three drugs (ipilimumab, nivolumab, and sacituzumab govitecan) as a first treatment for people with advanced bladder cancer who cannot take standard chemotherapy. About 46 adults will participate to find the best dose and see how well the drugs s…

This study tested whether taking the drug abiraterone on an on-and-off schedule could help it work longer for men with advanced prostate cancer that no longer responds to hormone therapy. Nineteen men whose cancer had already responded to standard daily abiraterone were enrolled.…

This phase 2 trial tests a sequential treatment approach for men with high-risk metastatic prostate cancer that is still sensitive to hormone therapy. In the first step, patients receive hormone therapy (LHRH analog plus a newer hormonal drug like abiraterone or enzalutamide). In…

This early-phase trial tests an adaptive approach to hormone therapy for men with stage IV prostate cancer that still responds to hormone treatment. Instead of a fixed schedule, the treatment is adjusted based on PSA levels. The study includes 17 participants and combines standar…

This early-stage trial tests a new way to treat high-grade bladder cancer that hasn't spread into the muscle. Doctors take immune cells from the patient's own tumor, grow them in a lab, and put them back into the bladder. The goal is to see if this is safe and can shrink or elimi…

This study tests four different chemotherapy schedules in children and adults with a rare, aggressive muscle cancer that has spread. Participants choose from a first-strike approach, a first-strike followed by maintenance, an adaptive schedule, or standard chemo. The goal is to s…

This early-stage trial tests two drugs together—canakinumab and darbepoetin alfa—in people with a lower-risk form of myelodysplastic syndromes (MDS) whose previous treatment stopped working. The goal is to see if the combination is safe and can help the body make more red blood c…

This study tests a health workshop for Latino parents of children aged 6 to 12 living in rural Florida. The workshop teaches healthy eating, physical activity, and sun protection to help reduce cancer risk. Researchers will check if families find the program useful and if it help…

This study tests two different vaccines designed to prevent HER-2 positive breast cancer from coming back in people who have already completed initial treatment. About 119 participants who had surgery after chemotherapy will receive one of the two vaccines, followed by booster sh…

This study tests ways to increase HPV vaccination among 11-17 year olds at 8 community health centers in Florida. It provides training for doctors and nurses on how to recommend the vaccine, and gives parents easy-to-understand information before visits. The goal is to see if the…

This study tests a program called CARES-REACH that trains healthcare providers and uses electronic medical record tools to increase colorectal cancer screening rates in rural clinics. Researchers are working with 49 staff and providers from two healthcare systems. The goal is to …

This study tests whether a natural compound called delta-tocotrienol (a form of vitamin E) can prevent pancreatic cysts (IPMNs) from growing or turning into cancer. About 4 adults with IPMNs that are being watched but not yet dangerous will receive either the supplement or a plac…

This study tests a procedure called prostatic artery embolization (PAE) in 17 men with low-risk prostate cancer who also have trouble urinating. The goal is to see if PAE can reduce urinary symptoms before they start radiation therapy. Participants will have their symptoms and pr…

This study looks at whether a mindfulness-based stress management program can lower the stress and burden felt by caregivers of patients receiving a stem cell transplant (allogeneic HCT). About 505 caregivers and patients are taking part. The program uses a smartphone app to teac…

This study tests a program called STRONG that gives pancreatic cancer patients extra support from a dietician and a Fitbit to track their food intake. The goal is to see if patients find the program helpful and easy to stick with while they are on chemotherapy. About 80 adults wi…

This study tests whether a program combining resistance training and a Mediterranean diet is practical and helpful for people with head and neck cancer undergoing radiation. Forty participants will receive supervised exercise sessions and pre-made meals, plus dietary coaching. Th…

This study tests a program that provides remote nutrition counseling and uses a Fitbit to track activity and diet for people with gastroesophageal cancer. Participants log their food intake and meet with a dietitian via video calls. The goal is to see if this approach is practica…

This study is creating a biobank—a collection of blood, tumor tissue, and health data—from 500 people with pancreatic cancer. Researchers want to learn why some groups are affected more than others and how cachexia (severe weight loss) develops. Participants donate samples and fi…

This study tests a web-based tool called REFLECT, designed to help adolescent and young adult cancer patients learn about fertility and genetic risks for future children. Sixteen participants who have had cancer care at Moffitt Cancer Center will use the tool and rate how easy an…

This study looks at how quality of life differs among older adults (60+) newly diagnosed with acute myeloid leukemia (AML) who receive either intensive or non-intensive chemotherapy. Researchers aim to build a decision-making model that helps patients and doctors choose treatment…

This study aimed to compare a newer breathing machine method (APRV) with the standard method (CMV) during anesthesia for robotic gynecologic or genitourinary cancer surgery. The goal was to find the best settings to help patients' lungs work well during the procedure. However, th…

This study collects health information and test results from 317 people at high risk for pancreatic cancer, including those with cysts, genetic syndromes, or other risk factors. Researchers aim to build a database to find better ways to detect the disease early or prevent it. No …

This study looks at whether a 12-week program of cooking demonstrations, recipe cards, and free fruit and vegetable bundles can help cancer survivors eat healthier. Only 11 people are taking part, and the main goal is to see if such a program is practical and keeps people interes…

This study looks at 69 people with multiple myeloma who had a stem cell transplant. It compares those who take one maintenance drug versus two drugs (an immunomodulatory agent plus a proteasome inhibitor) to see which keeps the cancer away longer. The goal is to learn if the two-…

This study looks at whether the Decipher test, which predicts how aggressive prostate cancer is, works the same for African-American men as for other men. The test was developed mainly from samples of European men, but African-American men have higher rates of prostate cancer and…

This study looks at whether non-invasive tests—like blood, urine, and genetic analysis—can help track prostate cancer progression without repeated biopsies. Researchers will follow 500 men with low, intermediate, or high-risk prostate cancer as they receive standard care. The goa…

This study looks at the lifestyle habits and quality of life of young adults who had cancer between ages 19 and 29. Researchers will use surveys and fitness trackers to understand current behaviors and then create a personalized diet and exercise program. The goal is to help surv…

This study looks at whether a home-based exercise program is practical and safe for people aged 65 and older who are waiting for liver or bile duct cancer surgery. About 25 participants will do supervised exercise sessions and be tracked for how many join, stick with it, and repo…

Researchers at Moffitt Cancer Center are studying whether tiny plastic particles, called microplastics, are present in the lungs of people with and without lung cancer. They will collect fluid from the lungs during a standard bronchoscopy procedure and analyze it for microplastic…