H. Lee Moffitt Cancer Center And Research Institute

This study is testing whether adding culturally-relevant stress management techniques to a standard weight loss program helps Black women with obesity lose more weight. Over 300 participants are randomly assigned to receive either the standard program or the enhanced version with…

This study is testing whether using MRI scans during radiation treatment can help doctors better target head and neck cancer tumors while reducing damage to nearby healthy organs. The trial involves 25 patients and aims to personalize the radiation dose based on how the tumor res…

This early-phase study is testing a personalized vaccine for people with HER2-positive breast cancer. The vaccine is made from the patient's own immune cells and is designed to teach the body's immune system to attack the cancer. Researchers are giving the vaccine alongside stand…

This early-phase study is testing whether using MRI scans to guide and adjust radiation therapy in real-time is a practical approach for treating rectal cancer. It involves 20 adults with locally advanced rectal adenocarcinoma who have not had prior pelvic radiation. The main goa…

This small, early-stage study is testing whether combining a special light treatment (phototherapy) with the drug mogamulizumab works better for people with early-stage mycosis fungoides, a type of skin lymphoma. The goal is to see if this combination can better control the disea…

This study is testing whether combining two drugs, binimetinib and belinostat, can shrink tumors or stop them from growing in adults with metastatic uveal melanoma, a rare and aggressive cancer that starts in the eye. The goal is to see if this combination is effective at control…

This study is testing whether two immunotherapy drugs, nivolumab alone or combined with azacitidine, are safe and can help prevent cancer from coming back in patients with recurrent osteosarcoma (a type of bone cancer) that has spread to the lungs but can be surgically removed. P…

This study is testing a procedure called prostatic artery embolization (PAE) in men with early-stage prostate cancer who have bothersome urinary symptoms and are planning to get radiation therapy. Doctors inject tiny particles to block blood flow to the prostate, aiming to shrink…

This study is testing if giving the immunotherapy drug cemiplimab to patients before their tumor removal surgery is safe and helps control their cancer. It is for adults with early-stage Merkel cell carcinoma or locally advanced squamous cell carcinoma who are scheduled for surge…

This study is testing whether adding an older drug called DFMO to the immunotherapy pembrolizumab can help control advanced lung cancer in people whose tumors have a specific genetic change (STK11 mutation). The first part finds the safest dose, and the second part checks if the …

This study is testing whether giving two drugs, lenvatinib and pembrolizumab, before surgery can help people with Merkel cell carcinoma, a rare and aggressive skin cancer. The goal is to shrink the tumor as much as possible to make surgery more effective and potentially improve l…

This study tests whether personalized phone counseling and text messages help cervical cancer survivors quit smoking and stay smoke-free for two years. Researchers are comparing this approach to standard quitline support. The study involves 360 participants in Florida who have a …

This study is testing a two-step treatment plan for men with high-risk prostate cancer that has spread. First, patients receive strong hormone-blocking drugs. Then, they receive chemotherapy combined with hormone therapy. The goal is to see if this sequence can better control the…

This study aims to determine which maintenance therapy works better to control multiple myeloma after a stem cell transplant. Researchers are comparing patients who receive one maintenance drug versus those who receive two drugs together. The study will track 69 patients to see w…

This study is testing whether a flexible, 'adaptive' approach to hormone therapy, combined with a chemotherapy drug called docetaxel, can help men with advanced prostate cancer stay responsive to standard hormone treatments for a longer period. The goal is to delay the cancer's p…

This study is testing whether a flexible, 'adaptive' dosing schedule for a two-drug combination is a practical approach to treat advanced kidney cancer. It will involve about 75 adults with a specific type of kidney cancer who have not yet received any treatment for their advance…

This small, early study is testing a new way to take the prostate cancer drug abiraterone. It aims to see if stopping the drug when PSA levels drop, and restarting only when they rise again, can help control the cancer longer while keeping patients feeling well enough for daily a…

This early-stage study is testing whether adding a drug called romidepsin directly into the bladder can help another drug (durvalumab) work better against muscle-invasive bladder cancer. It is for patients who are not eligible for standard cisplatin chemotherapy. The main goal is…

This study is testing if the drug fedratinib is effective and safe for people with rare, hard-to-treat blood cancers. It will involve about 25 adults with specific conditions like MDS/MPN or chronic neutrophilic leukemia. The main goal is to see if the drug can control the diseas…

This small, early-stage study is testing if doing 30 minutes of moderate exercise right before standard immunotherapy can help the treatment work better against certain skin cancers. Researchers will enroll 22 adults with melanoma, squamous cell carcinoma, or Merkel cell carcinom…

This early-stage trial tests whether infusing specially prepared immune cells from a transplant donor can prevent acute myeloid leukemia from returning in high-risk patients. Researchers will determine the safest dose and see if this approach improves survival without causing har…

This study is testing whether combining three existing drugs—nivolumab, ipilimumab, and nintedanib—is safe and effective for people with advanced non-small cell lung cancer (NSCLC). It will enroll about 66 adults whose cancer has spread and has no curative treatment options. The …

This study is testing whether an automated video-based treatment program can help people living with HIV quit smoking for good. It compares this easier-to-access video program to a more intensive standard treatment. The goal is to find the most effective way to support long-term …

This study is testing four different ways to time chemotherapy for a rare and aggressive type of childhood muscle cancer that has spread. The goal is to see if changing when and how chemotherapy is given can better control the cancer and prevent it from coming back. Patients and …

This early-stage study aims to find the highest safe dose of a new drug called XL888 when given with two existing melanoma drugs (vemurafenib and cobimetinib). It involves 26 adults with advanced, BRAF-mutated melanoma that cannot be removed by surgery. The main goals are to dete…

This early-stage study is testing the safety of a new combination treatment for people with advanced head and neck cancer that has come back or spread. Doctors take a patient's own immune cells from a tumor, grow and select them in a lab, and then infuse them back along with an i…

This early-stage study is testing the safety of combining two drugs—an oral chemotherapy called capecitabine and an immunotherapy drug called cemiplimab—for people with advanced hormone-positive breast cancer. The main goal is to find the safest and most effective dose for future…

This early pilot study is testing whether using a flexible on-and-off schedule for three cancer drugs works better for people with advanced melanoma that has a specific BRAF gene mutation. The drugs combine targeted therapy (encorafenib and binimetinib) that blocks cancer cell gr…

This early-stage study is testing whether combining two existing cancer drugs—ceritinib and docetaxel—can help control advanced lung cancer that has stopped responding to standard chemotherapy. The trial aims to find the safest dose of this combination and see if it can shrink tu…

This study is testing whether the drug ruxolitinib can help control Chronic Myelomonocytic Leukemia (CMML), a rare blood cancer. Researchers are enrolling 29 adults with CMML who have significant symptoms or an enlarged spleen. The main goal is to see if the treatment reduces sym…

This study is testing whether combining two drugs—canakinumab and darbepoetin alfa—can help patients with lower-risk myelodysplastic syndromes (MDS) who no longer respond to standard anemia treatments. The trial will first determine the safest dose and then see if the combination…

This study is testing whether using a special vacuum device on surgical wounds helps prevent infections in people recovering from gastrointestinal cancer surgery. Researchers are comparing the vacuum therapy to standard wound dressings in 290 patients. The main goal is to see if …

This study is testing whether adding a precise, high-dose radiation treatment (SBRT) to a two-drug immunotherapy combination works better for controlling advanced Merkel cell carcinoma. It will compare the standard immunotherapy pair (nivolumab and ipilimumab) against the same dr…

This study is testing whether a free, automated smartphone app can help people quit smoking. It enrolled 520 adult smokers who use a food bank and have a smartphone. Researchers are checking if the app helps people stop smoking and for how long, using both participant reports and…

This early-stage trial is testing whether giving chest radiation followed by one of three immunotherapy drug regimens can help control advanced small cell lung cancer for longer. It is for patients whose cancer has stopped growing or shrunk after initial chemotherapy. The main go…

This study is testing if giving a short, focused course of radiation right before surgery helps keep brain tumors from coming back longer than the current standard approach. It involves 49 adults with cancer that has spread to the brain from elsewhere in the body, where the main …

This early-stage study is testing a personalized treatment called TBio-4101 for people with advanced melanoma that hasn't responded to standard therapies. Doctors take immune cells from a patient's tumor, grow them in large numbers in a lab, and then infuse them back into the pat…

This study is for people with chronic myeloid leukemia (CML) who had to restart their daily pills after trying to stop them once. Researchers want to see if adding a drug called ruxolitinib to their current CML medication for a year can help them successfully stop all treatment f…

This study is testing a flexible treatment strategy for older adults with newly diagnosed multiple myeloma, a blood cancer. Patients first receive a two-drug combination, and doctors then adjust their treatment based on how well they respond. The goal is to control the disease ef…

This is an early-stage study to see if a new type of cell therapy is safe and feasible for people with a specific type of bladder cancer that has come back after standard treatment. The therapy involves collecting a patient's own immune cells from their tumor, growing more of the…

This early-stage study is testing a personalized, 'adaptive' treatment approach for men with advanced prostate cancer that has spread but still responds to hormone-blocking therapy. The goal is to see if adjusting the timing and dose of standard hormone therapy based on a patient…

This study is testing if combining two existing cancer drugs, pembrolizumab and vorinostat, is safe and works better than pembrolizumab alone for people with advanced lung cancer that has spread. It will involve about 120 adults whose cancer has progressed after at least one prio…

This study is testing whether adding an immunotherapy drug called nivolumab (Opdivo) to standard radiation and hormone therapy is safe and can help men with a very aggressive form of prostate cancer. The goal is to see if this combination can better control the cancer and prevent…

This study is testing whether a daily green tea extract pill can help control early-stage prostate cancer in men who are being monitored instead of immediately treated. 115 men will take either the green tea extract or a placebo pill for two years to see if it slows the cancer's …

This study is testing a combination of three drugs—ipilimumab, nivolumab, and sacituzumab govitecan—as a first treatment for advanced bladder cancer that has spread. It is for patients who are not eligible for the standard chemotherapy drug cisplatin. The first part of the study …

This study is testing whether combining a precise, high-dose radiation treatment (SBRT) with an immunotherapy drug (atezolizumab) works better than the drug alone for cervical cancer that has returned or spread. It involves about 21 women with advanced cervical cancer. The goal i…

This early-stage study is testing the safety of an experimental treatment called CG0070 for people with intermediate-risk bladder cancer that hasn't spread into the muscle wall. After surgeons remove visible tumors, researchers will deliver CG0070 directly into the bladder to see…

This study aims to determine if the Decipher® prostate cancer test predicts aggressive disease with the same accuracy in African-American men as in non-African-American men. The test was developed mainly using samples from men of European descent, and researchers want to validate…

This study is testing whether a combination of fish oil (Lovaza) and curcumin (from turmeric) can help reduce the size of small lung nodules found in former and current heavy smokers. The goal is to see if these natural supplements might help prevent lung problems before they bec…

This study is testing two different vaccines designed to prevent breast cancer from returning in patients with HER2-positive disease. It focuses on people who still had cancer cells remaining after completing their initial chemotherapy and targeted therapy. Researchers will monit…

This study is testing whether a form of vitamin E called tocotrienol can prevent a specific type of pancreatic cyst (IPMN) from growing or developing concerning features. Adults with small, low-risk IPMNs are randomly assigned to receive either the study compound or a placebo for…

This study aims to increase HPV vaccination rates among 11-17 year olds in Florida community health centers. Researchers will test strategies targeting parents, healthcare providers, and health centers to encourage more teens to start and complete the vaccine series. The study wi…

This study is testing whether giving a pneumonia vaccine before and after a powerful cancer treatment called CAR T cell therapy can better protect patients from serious infections. It involves 26 adults with certain types of B-cell lymphoma who are scheduled for CAR T therapy. Th…

This study is testing whether a 6-month diet and exercise program is practical and acceptable for people with certain non-cancerous pancreas growths (IPMNs) who are at higher risk for pancreatic cancer. It enrolled 24 adults to see if they can stick to activity goals and nutritio…

This study is testing whether a program of physical activity and a Mediterranean-style diet can help people feel better during and after treatment for head and neck cancer. It involves 40 adult survivors who are scheduled for radiation or chemoradiation. The main goal is to see i…

This study is testing whether mindfulness-based stress management programs can help reduce the emotional burden and stress experienced by caregivers of patients undergoing bone marrow transplants. The research involves 505 caregiver-patient pairs and compares different stress man…

This study aims to help young adults who have finished cancer treatment improve their quality of life through better diet and exercise habits. Researchers will first understand current lifestyle patterns among 100 young cancer survivors, then develop and test a personalized coach…

This study is testing whether a guided exercise program is safe, practical, and acceptable for older adults with liver cancer who are planning to have surgery. The main goal is to see if patients can and will participate in the program before their operation. Researchers will mea…

This study is testing whether a remote nutrition coaching program is practical and helpful for people with pancreatic cancer during their first 12 weeks of chemotherapy. It involves 40 participants who will receive coaching and monitoring over the phone or online. The main goal i…

This study is testing whether a remote support program that provides nutrition guidance is practical and helpful for people with esophageal or stomach cancer. The program uses a mobile app to help patients track their food while they are going through chemotherapy and radiation. …

This study is testing a remote nutrition support program for people with pancreatic cancer who are receiving chemotherapy. The program provides regular video visits with a dietitian and asks participants to track their food intake. Researchers want to see if this approach helps p…

This study is testing whether a remote support program is practical and helpful for people with pancreatic cancer. The program uses a phone app and video calls to provide nutritional advice and supportive care from specialists while patients are on chemotherapy. Researchers want …

This study is testing a 12-week 'culinary medicine' program for people who have had cancer. Participants receive biweekly bundles of fruits and vegetables, recipe cards, and attend cooking demonstrations to learn how to prepare healthy meals. The goal is to see if this practical …

This study is testing whether a pickleball program is a practical and well-liked way to help cancer survivors and their friends or family get more active and improve their overall wellness. Researchers are enrolling 28 participants to learn and play pickleball together. The main …

This study aims to find new, non-invasive ways to track prostate cancer by analyzing blood, urine, and tissue samples from patients. It will observe 500 men with different risk levels of prostate cancer who are receiving standard care. The goal is to discover biomarkers that coul…

This study is looking at how two different diets affect the community of bacteria living in people's guts. Researchers provided all meals for 28 days to 115 healthy Black and White adults in Alabama, comparing the DASH diet to a typical American diet. They collected stool samples…

This study aims to understand if tiny plastic particles in the air we breathe end up in our lungs and if they are connected to lung cancer. Researchers are analyzing lung fluid samples from 119 patients who are already scheduled for a standard lung washing procedure. The goal is …

This study is testing whether a special exercise program is safe and practical for older adults with blood cancers before they receive CAR-T cell therapy. Researchers want to see if patients can stick with the program and if it helps improve their strength and fitness. The goal i…

This study aims to understand how different treatments affect quality of life for older adults with acute myeloid leukemia (AML). Researchers are comparing quality of life between patients receiving intensive versus less intensive chemotherapy. The goal is to create a decision-ma…

This study aims to create a large database of patient information to find better ways to detect pancreatic cancer early, when it's most treatable. It involves 317 adults at Moffitt Cancer Center who have pancreatic cysts, a strong family history of pancreatic cancer, or other ris…

This study is testing a web-based education tool called REFLECT, designed to help young adult cancer patients understand their fertility options and genetic risks for future children. Researchers are evaluating how easy and useful the tool is for patients aged 18-39 who received …

This small pilot study aims to learn if a different setting on the breathing machine (APRV) works better than the standard setting (CMV) to support patients' lungs during robotic surgery for gynecologic or urinary tract cancers. The study will enroll 12 patients to compare how we…

This study is using a special type of PET scan to look at a specific target on aggressive neuroendocrine cancer cells in the digestive tract. Researchers want to see if enough of this target is present to potentially use a targeted radiation treatment in the future. The study inv…

This study aims to understand how a specific program helps increase colon cancer screening rates, especially in rural areas. It does not involve treating patients; instead, it collects information from healthcare providers and clinics. The goal is to learn which clinic procedures…

This study aims to create a large collection of blood and tissue samples from people with pancreatic cancer. Researchers will analyze these samples alongside medical records to understand why the disease affects different racial and ethnic groups differently. The goal is to find …