Radiation before brain surgery may keep tumors away longer

NCT ID NCT05267587

Ongoing Disease control Sponsor: H. Lee Moffitt Cancer Center and Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial is testing whether giving focused radiation before surgery for brain metastases can delay tumor regrowth better than standard care. About 49 adults with solid tumors (not lymphoma or germ cell) and at least one brain metastasis will receive three daily doses of radiation to the tumor before it is removed. The study measures how long it takes for the cancer to progress in the brain and overall survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hypofractionated stereotactic radiosurgery (focused radiation)
What this could lead to: If successful, this approach could reduce the chance of brain metastases returning after surgery, potentially improving local control and survival.
What could go wrong: This is a small, early-phase trial with only 49 participants, so results may not apply broadly. Radiation can cause side effects like swelling or damage to healthy brain tissue.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer metastatic malignant neoplasm in the brain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN LESION BRAIN METASTASES

Contacts and locations

Locations

Moffitt Cancer Center

Tampa, Florida, 33612, United States

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