New combo therapy aims to extend control of aggressive lung cancer

NCT ID NCT03923270

First seen Nov 01, 2025 · Last updated May 13, 2026 · Updated 27 times

Summary

This early-phase trial tests whether adding chest radiation followed by immunotherapy drugs (durvalumab alone or with tremelimumab or olaparib) can help control extensive-stage small cell lung cancer after initial chemotherapy. About 25 adults whose cancer did not worsen after first-line chemo will receive these treatments. The main goals are to check safety and see how long the cancer stays under control.

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Contacts and locations

Locations

  • H. Lee Moffitt Cancer Center and Research Institute

    Tampa, Florida, 33612, United States

Conditions

Explore the condition pages connected to this study.