New drug combo aims to tame myeloma in older patients without harsh chemo
NCT ID NCT04151667
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase II study tests a treatment plan using daratumumab (Darzalex) and dexamethasone for adults aged 65 and older with newly diagnosed multiple myeloma who cannot handle intensive chemotherapy. The goal is to see how well the combination controls the disease by measuring response rates. Thirty-three participants receive the drugs over several months, with the hope of offering a gentler yet effective option.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Daratumumab (Darzalex) and dexamethasone
What this could lead to
If successful, this could offer an effective treatment option for older adults with multiple myeloma who cannot tolerate intensive chemotherapy, potentially controlling the disease for longer.
What could go wrong
This is a small Phase II study with only 33 participants, so results may not apply to all patients. The treatment may not work as well as hoped, and side effects like infections or allergic reactions are possible.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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H. Lee Moffitt Cancer & Research Institute
Tampa, Florida, 33612, United States