H. Lee Moffitt Cancer Center And Research Institute

This early-phase study tested a personalized vaccine made from a patient's own immune cells, designed to target a protein called HER-2 found on some aggressive breast cancers. The goal was to see if the vaccine was safe and could train the immune system to prevent the cancer from…

This study tested a new approach for people with advanced melanoma that can be surgically removed. Participants received a combination of two immunotherapies: one injected directly into the tumor (Tavo) and one given through a vein (nivolumab). After 12 weeks, they had surgery to…

This study tested whether using a negative pressure wound therapy device (a special vacuum bandage) for a longer time after surgery could lower the chance of wound infections in people with gastrointestinal cancer. About 290 patients took part. The goal was to see if this approac…

This study tested a drug called fedratinib in 25 adults with rare blood cancers (MDS/MPN and CNL). The goal was to see if the drug could shrink the spleen and improve blood counts. While not a cure, the treatment aims to control the disease and reduce symptoms.

This pilot study tested a 4-month program that combines weight loss strategies with stress management techniques for Black breast cancer survivors who have obesity and high stress. The program is based on the Diabetes Prevention Program and includes 16 sessions. Researchers measu…

This early-phase study tested a vaccine made from patients' own immune cells to target HER2-positive breast cancer. 31 participants with stage II or III breast cancer received the vaccine alongside standard chemotherapy before surgery. The goal was to see if the vaccine could boo…

This early-phase study tested a combination of two drugs—capecitabine (a chemotherapy pill) and cemiplimab (an immunotherapy)—in 13 people with hormone receptor-positive breast cancer that had spread. The main goal was to find the safest dose and see if the combo could shrink tum…

This early study tested whether giving a single dose of nivolumab with either ipilimumab or relatlimab before surgery is safe and possible for people with melanoma that has spread to the brain. Only one person took part, so results are very limited. The goal was to see how the dr…

This study tested a combination of two immunotherapy drugs—high-dose interleukin-2 (IL-2) and pembrolizumab (Keytruda)—in 27 adults with metastatic kidney cancer. The goal was to see if the combination could shrink or eliminate tumors. Participants received both drugs in a coordi…

This study tested a combination of two chemotherapy drugs, nab-paclitaxel and gemcitabine, in 59 teenagers and young adults whose sarcoma (a type of bone or soft tissue cancer) had returned or not responded to standard treatment. The main goals were to see if the drug combo could…

This early-stage study tested whether adding a drug called BMS-986004 to standard immune-suppressing medicine could help prevent acute graft-versus-host disease (GVHD) in 45 adults with blood cancers or disorders receiving a stem cell transplant. GVHD occurs when donor immune cel…

This early-phase trial tested a new personalized therapy called TBio-4101 for people with advanced melanoma that had stopped responding to standard treatments. The therapy uses a patient's own tumor-fighting immune cells, which are collected, multiplied in the lab, and then infus…

This study tested whether adding pacritinib to standard immune-suppressing drugs (sirolimus and tacrolimus) could prevent graft-versus-host disease (GVHD) in 40 patients receiving stem cell transplants for blood cancers. GVHD occurs when donor immune cells attack the recipient's …

This study tested whether combining two FDA-approved cancer drugs, cetuximab and nivolumab, could help people with advanced head and neck cancer that has returned or spread. A total of 95 participants received the drug combination to find the best dose and see if it improves surv…

This small, completed study tested whether it is possible to personalize radiation doses for people with stage II or III non-small cell lung cancer based on the genetic profile of their tumor. Three participants received either standard or higher radiation doses depending on a ra…

This completed study tested a smartphone-based program to help 520 low-income smokers quit. Participants received nicotine patches and lozenges, plus automated app content and phone counseling. The goal was to see if this approach could boost quit rates in a hard-to-reach populat…

This phase 2 trial tested the immunotherapy drug nivolumab (Opdivo) in 54 patients with advanced biliary tract cancer that had stopped responding to chemotherapy. The goal was to see if the drug could shrink tumors. While nivolumab is approved for other cancers, it is not yet app…

This study tested whether injecting a modified herpes virus (T-VEC) directly into tumors, alongside standard chemotherapy before surgery, could better eliminate triple negative breast cancer. The virus is designed to infect and destroy cancer cells while leaving healthy cells alo…

This early-phase trial tested the drug avelumab (Bavencio) combined with whole-brain radiotherapy in 16 patients with leptomeningeal disease, a condition where cancer spreads to the lining of the brain and spinal cord. The main goal was to find a safe dose and check for side effe…

This phase 2 study tested a combination of two drugs, TAS 102 (Lonsurf) and ramucirumab (Cyramza), in 23 patients with advanced stomach or gastroesophageal junction cancer that had stopped responding to other treatments. The goal was to see if the combo was safe and could help pa…

This early-stage study tested a combination of two drugs—CG0070 (a virus that targets cancer cells) and nivolumab (an immunotherapy that boosts the immune system)—in 21 people with muscle-invasive bladder cancer who were not eligible for standard chemotherapy. The goal was to see…

This early-phase trial tested a combination of two oral drugs, trametinib and ceritinib, in 27 people with advanced melanoma that had stopped responding to prior treatments. The main goals were to find a safe dose and see if the combination could shrink tumors. The study is compl…

This early-phase trial tested a treatment that uses a patient's own immune cells (called TILs) to fight soft tissue sarcoma. Nine young adults received chemotherapy to prepare their bodies, then an infusion of their own TILs plus high-dose IL-2 to boost the immune response. The m…

This phase II trial tested a powerful combination for people with advanced melanoma that has spread. The approach uses a targeted drug (vemurafenib), immune cells grown from the patient's own tumor (TIL), and high-dose IL-2 to boost the immune system. The study enrolled 17 partic…

This phase 2 trial tested whether adding an experimental drug called AZD1775 to standard chemotherapy (carboplatin and paclitaxel) could help people with advanced squamous cell lung cancer. The study enrolled 42 participants and measured how long they lived without their cancer g…

This early-phase trial tested a new treatment for people with myelodysplastic syndrome (MDS) or secondary acute myeloid leukemia (AML) who had not responded to prior therapy. The treatment involved giving specially prepared donor immune cells (with CD8 cells removed to reduce ris…

This early-stage study tested whether combining a procedure that uses electrical pulses to destroy tumors (IRE) with an immunotherapy drug (pembrolizumab) is safe for people with locally advanced pancreatic cancer that cannot be removed by surgery. Only 2 participants were enroll…

This early-phase study tested a combination of two drugs, regorafenib and nivolumab, in 52 people with advanced colorectal cancer that had stopped responding to other treatments. The goal was to find the safest dose and see if the combination could help control the cancer. The st…

This early-phase study tested a new treatment called PRGN-3007 UltraCAR-T cells in 3 adults with advanced blood cancers (like leukemia and lymphoma) or triple-negative breast cancer. The goal was to find a safe dose and see if the therapy can shrink tumors. The study is now compl…

This phase 2 trial tested a combination of two drugs—pembrolizumab (Keytruda) and lenvatinib (Lenvima)—in 20 people with advanced neuroendocrine tumors that had worsened despite prior treatments. The goal was to see if the combination could shrink tumors or slow disease progressi…

This study tested a new way to treat metastatic melanoma by using a patient's own immune cells. Doctors removed a tumor, grew special immune cells (TILs) from it in a lab, then gave them back to the patient along with high-dose IL-2. Before the cell infusion, patients received st…

This study tested a new way to deliver chemotherapy directly to the tumor in adults with malignant pleural mesothelioma that cannot be removed by surgery. The treatment, called transarterial chemoperfusion, uses a combination of three drugs (cisplatin, methotrexate, and gemcitabi…

This phase 2 study tested a combination of three drugs—ofatumumab, high-dose methylprednisolone, and lenalidomide—in 45 people with untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The goal was to see if this approach could make all signs of cance…

This pilot study tested a new combination treatment for people with advanced melanoma that has spread. It combined a patient's own immune cells grown in a lab (called TILs) with an immunotherapy drug called ipilimumab. The main goals were to see if the treatment was safe and poss…

This study tested a stem cell transplant from half-matched (haploidentical) family donors for 34 people with various blood cancers. Patients received a reduced-intensity conditioning regimen of fludarabine, melphalan, and total body irradiation before the transplant. The goal was…

This early-phase trial tested a combination of two drugs — IRX-2 and durvalumab — in 19 people with advanced head and neck cancer that could not be cured by standard treatments. The goal was to see if the combination was safe and could boost the immune response inside tumors. The…

This early-phase study tested adding the drug pirfenidone to standard chemotherapy for people with advanced non-small cell lung cancer. The main goals were to find a safe dose and see if the combination could shrink tumors. 48 participants were enrolled, and the study is now comp…

This early-phase study tested a new drug combination (duvelisib plus BMS-986345) in 14 people with blood cancers like lymphoma, myeloma, and leukemia. The main goal was to find a safe dose and check for side effects. Researchers also looked at how well the cancer responded after …

This early-phase study tested whether combining stereotactic radiosurgery (precise radiation) with the immunotherapy drug nivolumab (Opdivo) is safe and can shrink tumors in people with breast cancer that has spread to the brain. Fourteen participants received the combination. Th…

This early-phase trial tested the safety of adding two drugs, pembrolizumab and vorinostat, to standard chemotherapy and radiation for people newly diagnosed with glioblastoma, an aggressive brain cancer. The study enrolled 21 participants to find the highest safe dose of vorinos…

This study looked at whether giving people personalized information about their genetic risk for melanoma could encourage them to protect themselves from the sun. Over 2,000 adults received either standard sun safety tips or tailored advice based on their DNA. Researchers then tr…

This study tested whether a remote nutrition coaching program is practical and well-liked by people with pancreatic cancer who are undergoing chemotherapy. Forty participants were asked to complete online food questionnaires and attend coaching sessions over 12 weeks. The goal wa…

This study tested whether a remote resistance training program is feasible and safe for people with advanced upper gastrointestinal cancer who are on chemotherapy. Twenty-two participants were asked to do strength exercises at home using video guidance. The study measured how man…

This study tested a program to help lung cancer patients stop smoking and avoid starting again. 21 adults with lung cancer who smoked took part. The program included counseling, a web video, and support calls. The goal was to see if the program was easy to use and if patients lik…

This completed Phase 1 trial tested a smartphone app that uses mindfulness exercises to help cancer survivors quit smoking. Twelve participants used the app daily for three weeks, completed surveys, and received nicotine patches. The goal was to see if people liked the app and fo…

This study tested a program that provides nutrition and supportive care remotely to adults with pancreatic cancer who are receiving chemotherapy. The goal was to see if the program was easy to use and if patients were satisfied with it. 50 participants were enrolled to track how …

This study tested whether a pickleball program is practical and enjoyable for cancer survivors and their family or friends. The goal was to increase physical activity and improve overall wellness. 28 participants joined the program, which involved learning and playing pickleball …

This study tested whether a web-based tool called eSNAP, combined with a caregiver navigator, could help family caregivers of brain cancer patients feel less anxious and burdened. The tool helps caregivers map out their support network, while the navigator provides guidance. Rese…

This pilot study tested a 12-week digital health coaching program for people with pancreatic cancer and their caregivers. The program included coaching sessions by phone, text, or email to help manage symptoms. The study aimed to see if the program was easy to use and if particip…

This study looked at whether eating only during an 8-10 hour daytime window (without cutting calories) could help immunotherapy work better in people with advanced head and neck cancer. 29 patients were asked to follow this eating pattern, and researchers tracked how well they st…

This study tested a 12-week program that gave nutrition counseling and a Fitbit app to 10 people with gastrointestinal cancer who had surgery and chemotherapy. The goal was to see if the program was easy to use and if patients liked it. Researchers measured how many people joined…

This study tested a mobile health (mHealth) program designed to help people who have had a stem cell transplant for blood cancer get better sleep. Researchers wanted to see if the program was easy to use and if participants liked it. About 30 survivors, caregivers, and doctors ga…

This study looked at whether using a person's DNA to pick an antidepressant works better than usual care for cancer patients with depression or anxiety. About 99 adults with cancer took part. Half got a DNA-guided choice of medication, and the other half got standard care. Resear…

This study tested a mindfulness-based treatment (MBRP) combined with cognitive behavioral therapy to help people reduce alcohol use and quit smoking. 67 adults who smoked and drank heavily participated. The goal was to see if the program was practical and satisfying for patients,…

This study tested whether a smartphone app could help patients with advanced kidney cancer learn about and manage side effects from combination immunotherapy. Twenty patients used the app for six weeks. The goal was to see if patients found the app helpful and if it improved thei…

This study tested a smartphone app that uses augmented reality to help reduce cravings to smoke. 14 adults who recently quit smoking tried the app and rated how easy it was to use and how much they liked it. The goal was to see if the app could be a helpful tool for quitting smok…

This study looked at how the DASH diet changes gut bacteria compared to a standard American diet. Over 100 Black and white adults in Alabama ate either the DASH diet or a typical diet for 28 days. Researchers measured changes in gut microbes, bile acids, and inflammation to see i…

This study looked at whether an exercise program is practical for people aged 65 and older with blood cancers like lymphoma, leukemia, or myeloma who are about to receive CAR T-cell therapy. The program included remote exercise sessions and was tested with 20 participants to see …

This study tested a new device called the EnVisio SmartClip that helps doctors mark and find breast tumors during surgery. 50 people with breast cancer took part. The goal was to see if the SmartClip makes it easier for surgeons to locate and remove the right tissue.

This study gave educational materials about colorectal cancer and screening to 188 adults aged 45-75 in the Tampa Bay area. Researchers used surveys to measure changes in knowledge and screening intentions. The goal was to see if education encourages people to talk to their docto…

This study looked at 30 adults with a rare, fast-growing type of gut cancer called poorly differentiated neuroendocrine carcinoma. Researchers used a special PET scan (68Ga-DOTATATE) to measure how much of a protein called somatostatin receptor is present on tumors. The goal was …

This study followed 60 adults with diffuse large B-cell lymphoma or transformed lymphoma who received commercial axi-cel therapy. Researchers measured changes in memory, attention, executive function, hand strength, and quality of life using surveys and cognitive tests. The goal …

This study tested whether a mathematical model could help doctors choose the best radiation schedule for people with HPV-positive throat cancer. The goal was to see if personalized dosing could shrink tumors faster than standard treatment. Fifty-five adults took part, and researc…

This study tested whether a culturally tailored educational program could improve people's understanding of clinical trials. 85 adults from the Tampa Bay area attended a session led by a community health educator. Participants completed surveys before and after to see if their kn…

This completed study involved 100 men aged 40 and older, with no personal history of prostate cancer, to understand their beliefs about genetic risk for the disease. Participants filled out a questionnaire and were asked to provide a saliva sample for genetic testing. The goal wa…

This completed study created a biobank of saliva, tumor tissue, and questionnaire data from 592 African American men with prostate cancer in Florida. Researchers want to see if smoking is linked to more aggressive prostate cancer. Participants filled out surveys and provided samp…