H. Lee Moffitt Cancer Center And Research Institute

This small pilot study tested whether combining two different immune-boosting treatments could help control advanced melanoma. Researchers collected cancer-fighting immune cells from patients' tumors, grew them in a lab, and then gave them back along with a drug called ipilimumab…

This early-stage trial tested adding an approved lung fibrosis drug, pirfenidone, to standard first-line chemotherapy for people with advanced non-small cell lung cancer. The main goals were to find a safe combined dose and get early signs of whether the combination could help sh…

This study tested whether combining two chemotherapy drugs, nab-paclitaxel and gemcitabine, could help control cancer in teenagers and young adults whose bone or soft tissue sarcoma had returned or stopped responding to standard treatments. The main goals were to see if the combi…

This early-stage study tested whether combining two treatments is safe for people with advanced pancreatic cancer that hasn't spread. First, doctors used electricity to destroy tumor cells (irreversible electroporation), then gave an immunotherapy drug (pembrolizumab) to help the…

This early-phase study tested whether combining a precise form of radiation (stereotactic radiosurgery) with an immunotherapy drug (nivolumab) is safe and can help control breast cancer that has spread to the brain. It involved 14 adults with metastatic breast cancer and brain tu…

This study tested whether the immunotherapy drug nivolumab could help control advanced bile duct cancer that had stopped responding to standard chemotherapy. The trial enrolled 54 adults whose cancer had progressed after one or two prior treatments. Researchers measured whether t…

This early-stage trial tested whether a personalized immune cell therapy is safe for young adults with advanced soft tissue sarcoma. Doctors collected each patient's own tumor-fighting immune cells, grew them in a lab, and then infused them back after a brief chemotherapy treatme…

This study developed and tested a mindfulness-based group program designed to help people quit smoking and reduce heavy alcohol use at the same time. It involved 67 adults in the Tampa Bay area who were motivated to make these changes. Researchers measured whether participants fo…

This study investigated whether restricting daily eating to an 8-10 hour window improves how well immunotherapy works for people with advanced head and neck cancer. It involved 29 patients and did not require calorie restriction, just timing. Researchers also looked at changes in…

This study tested a two-part immunotherapy for people with advanced melanoma that could still be removed by surgery. The goal was to see if giving a new drug (Tavo) injected directly into the tumor, along with a standard immunotherapy (nivolumab) given by IV, before surgery could…

This study tested a combination of three medications—ofatumumab, methylprednisolone, and lenalidomide—for people newly diagnosed with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The main goal was to see if this treatment could effectively control the c…

This early-stage study tested whether combining two existing cancer drugs (pembrolizumab and vorinostat) with standard chemotherapy and radiation is safe for people newly diagnosed with glioblastoma, an aggressive brain tumor. The trial involved 21 participants to determine the h…

This study tested whether combining two drugs, TAS-102 and ramucirumab, is safe and can help people with advanced stomach or gastroesophageal cancer that has stopped responding to other treatments. It involved 23 patients to see if the combination could help them live longer and …

This early-stage study aimed to find a safe dose of a new drug combination (BMS-986345 plus duvelisib) for patients with advanced blood cancers like lymphoma and leukemia. It involved 14 adults whose cancers had progressed after other treatments. The main goal was to check for si…

This study tested whether a mathematical model could help doctors choose the best radiation schedule for patients with HPV-positive throat cancer. The goal was to see if this personalized approach could make tumors shrink faster during treatment. The study involved 55 adults with…

This study tested the safety of a new type of donor immune cell infusion for patients with advanced myelodysplastic syndrome (MDS) or secondary acute myeloid leukemia (AML) after their initial treatments stopped working. The goal was to see if these specially prepared cells from …

This early-stage study tested the safety of combining two immunotherapy drugs, IRX-2 and durvalumab, for patients with incurable head and neck cancer. The main goal was to find the highest dose patients could tolerate without severe side effects and to see if the treatment increa…

This study tested whether combining two existing cancer drugs, pembrolizumab and lenvatinib, could help control advanced neuroendocrine tumors that had worsened despite previous treatments. It involved 20 adults whose cancer had spread and was still growing. The main goals were t…

This early-stage study tested the safety and highest tolerable dose of a new, genetically modified immune cell therapy called PRGN-3007 UltraCAR-T in adults with advanced blood cancers and triple-negative breast cancer. The main goal was to see how much of the treatment patients …

This small pilot study tested a program designed to help lung cancer patients quit smoking and prevent relapse. The program combined phone coaching, educational videos, and standard quit-smoking support. Researchers measured whether patients found the program helpful and complete…

This study tested the safety and best dose of a combination of two drugs, regorafenib and nivolumab, for people with advanced colorectal cancer that had stopped responding to standard treatments. The main goal was to see how much of the drug combination patients could tolerate an…

This study tested whether combining two existing cancer drugs, cetuximab and nivolumab, could help people with advanced head and neck cancer that had returned or spread. The first part aimed to find the safest dose of the combination. The second part aimed to see if this combinat…

This study tested whether adding an experimental drug called AZD1775 to standard chemotherapy (carboplatin and paclitaxel) could help control advanced squamous cell lung cancer. It involved 42 adults whose cancer had spread and had no known curative options. The main goal was to …

This study tested a combination of two drugs, pembrolizumab (Keytruda) and interleukin-2 (Proleukin), to treat kidney cancer that had spread. The goal was to see if using these two immune-boosting drugs together could better control the cancer. The trial involved 27 adults with a…

This study tested whether injecting a specially modified cold sore virus directly into breast tumors during chemotherapy before surgery could help eliminate cancer more effectively. The virus is designed to attack cancer cells and may help the patient's own immune system fight th…

This early-stage study tested the safety and initial effectiveness of combining two existing cancer drugs, trametinib and ceritinib, in patients with advanced melanoma that could not be surgically removed. It involved 27 patients whose cancer had worsened despite previous standar…

This study tested a less intense bone marrow transplant procedure for adults with various blood cancers who needed a transplant but did not have a fully matched donor. It used stem cells from a half-matched family member (like a parent, child, or sibling) after a milder pre-trans…

This small, early-stage study explored whether doctors could use a patient's unique tumor genetics to personalize their radiation dose. It involved people with stage 2 or 3 non-small cell lung cancer that couldn't be removed by surgery. The main goal was to see if this tailored a…

This small, early-stage study tested the safety of a two-part treatment for muscle-invasive bladder cancer in patients who could not receive standard chemotherapy. The treatment combined a modified cold virus (CG0070) placed directly into the bladder with an immunotherapy drug (n…

This study tested a multi-step treatment for advanced melanoma that had spread. Doctors took a patient's own tumor-fighting immune cells, grew billions of them in a lab, and then infused them back. This was combined with a targeted drug and chemotherapy to try to boost the immune…

This study tested whether delivering chemotherapy drugs directly to the tumor through blood vessels could help control advanced pleural mesothelioma. The trial involved 34 adults whose cancer couldn't be removed by surgery and who hadn't responded to standard chemotherapy. Resear…

This early-stage study aimed to find a safe dose of a two-part treatment for patients with leptomeningeal disease, a serious condition where cancer spreads to the fluid around the brain and spine. Sixteen patients received the immunotherapy drug avelumab along with whole brain ra…

This study tested a personalized treatment for advanced melanoma that had spread. Doctors took a patient's own cancer-fighting immune cells from a tumor, grew large numbers of them in a lab, and then put them back into the patient's bloodstream. The goal was to see if this approa…

This study tested a new device called the SmartClip to see if it helps surgeons accurately locate and remove breast tumors during cancer surgery. Doctors placed the clip in the breast before surgery and used a navigation system to find it during the operation. The goal was to see…

This study tested whether telling people about their genetic risk for skin cancer would change their sun safety habits. Over 2,000 adults, including Hispanic and non-Hispanic white participants, provided a saliva sample for genetic testing. Researchers then measured if receiving …

This study tested if adding a new drug called BMS-986004 to standard anti-rejection medicine could safely prevent a serious complication called acute Graft-Versus-Host Disease (GVHD). It involved 45 patients with blood cancers who received a stem cell transplant from a donor. The…

This early-stage study tested a personalized vaccine designed to teach the immune system to attack breast cancer cells, aiming to prevent the cancer from returning. It involved 15 women with a high-risk form of breast cancer who had no detectable disease after initial treatment. …

This study tested if adding a drug called pacritinib to standard anti-rejection medicines could better prevent graft-versus-host disease (GVHD) after a stem cell transplant. It involved 40 patients with blood cancers who received matched donor transplants. Researchers measured in…

This study tested if using a patient's genetic information (DNA) to guide the choice of antidepressant medication works better than standard doctor-led care for cancer patients. 99 adults with cancer and symptoms of depression or anxiety were randomly assigned to either get a DNA…

This study tested a new smartphone app designed to help cancer survivors quit smoking. Twelve participants tried the app, which offered mindfulness exercises, along with counseling and nicotine patches. The main goal was to see if people found the app easy to use and helpful for …

This study tested whether a digital support program and a dedicated guide could help family caregivers of brain cancer patients feel less stressed, anxious, and burdened. It involved nearly 300 caregivers and their patients. The goal was to see if this support system improved the…

This study tested whether a custom smartphone app could help people with advanced kidney cancer who are receiving combination immunotherapy. The app provided education about their condition and treatment, and helped monitor their well-being. Researchers wanted to see if patients …

This study tested a remote support program to help people with gastrointestinal cancer eat well during and after treatment. It involved 10 patients who had recently undergone major surgery. The goal was to see if the program was practical and if patients found it helpful, using t…

This small study tested whether a smartphone app using augmented reality (AR) could help people manage cravings while trying to quit smoking. The app was designed to be an engaging tool used alongside standard telephone quitline counseling. Researchers primarily wanted to see if …

This small, early study tested a 12-week digital health coaching program delivered via a mobile app for people with pancreatic cancer and their caregivers. The main goal was to see if the program was easy to use, acceptable to participants, and practical to run. Researchers measu…

This study tested a new phone app designed to help bone marrow transplant survivors who struggle with poor sleep. First, researchers interviewed survivors, caregivers, and doctors to design the program. Then, 30 survivors tried the app, which provided sleep tips and could connect…

This study aimed to understand how a specific cancer treatment called axi-cel (a type of CAR-T cell therapy) affects patients' thinking, memory, mood, and daily life. Researchers followed 60 adults with certain types of lymphoma who were scheduled to receive this commercial thera…

This study aimed to create a first-of-its-kind collection of health information and biological samples from African American men in Florida diagnosed with prostate cancer. Researchers enrolled 592 participants to build this resource, which will help scientists study the disease i…

This study tested whether an educational program could improve people's understanding of clinical trials and their willingness to join one. Researchers worked with 85 adults in the Tampa Bay area, teaching them about how trials work, their risks and benefits, and the consent proc…

This study explored how men without prostate cancer think about their genetic risk for the disease. Researchers asked 100 racially diverse men, particularly focusing on men of African ancestry, about their risk perceptions and willingness to provide saliva samples. The saliva was…

This small, early study tested the safety and feasibility of giving a single dose of one of two different drug combinations to patients with melanoma that had spread to the brain. The patients then had surgery to remove the brain tumor 7-10 days later. The main goal was to see if…

This study aimed to see if providing educational materials about colorectal cancer screening would increase people's knowledge and encourage them to get screened. Researchers worked with 188 adults aged 45-75 in the Tampa Bay area, providing information on screening recommendatio…