Triple threat against melanoma: drug + supercharged immune cells show promise
NCT ID NCT01659151
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II trial tested a powerful combination for people with advanced melanoma that has spread. The approach uses a targeted drug (vemurafenib), immune cells grown from the patient's own tumor (TIL), and high-dose IL-2 to boost the immune system. The study enrolled 17 participants and measured how many were alive and tumor-free at 12 months. Because it was small and had no comparison group, the results are preliminary but may guide future research.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Vemurafenib (Zelboraf), tumor-infiltrating lymphocytes (TIL), and high-dose interleukin-2 (IL-2, aldesleukin)
What this could lead to
If this combination works, it could point toward a more effective treatment for advanced melanoma that uses the body's own immune cells.
What could go wrong
This was a very small, early-phase trial (17 people) with no control group, so results may not apply broadly. The treatment involves strong chemotherapy and high-dose IL-2, which can cause serious side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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H. Lee Moffitt Cancer Center and Research Institute
Tampa, Florida, 33612, United States