Promising drug cocktail targets tough sarcomas in young patients

NCT ID NCT02945800

Completed Disease control Sponsor: H. Lee Moffitt Cancer Center and Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a combination of two chemotherapy drugs, nab-paclitaxel and gemcitabine, in 59 teenagers and young adults whose sarcoma (a type of bone or soft tissue cancer) had returned or not responded to standard treatment. The main goals were to see if the drug combo could shrink tumors or stop them from growing, and to check how safe and tolerable the treatment was. Participants received the drugs in cycles, and their tumors were measured with scans every two cycles.

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Conditions

The condition(s) this trial relates to.

Ewing sarcoma osteosarcoma Recurrence rhabdomyosarcoma sarcoma soft tissue sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EWING SARCOMA OSTEOSARCOMA RHABDOMYOSARCOMA SOFT TISSUE SARCOMA

Contacts and locations

Locations

A.I. duPont Hospital for Children, Delaware - Nemours

Wilmington, Delaware, 19603, United States
Carolinas Medical Center, Levine Cancer Institute

Charlotte, North Carolina, 28303, United States
Children's Hospital Los Angeles

Los Angeles, California, 90027, United States
Connecticut Children's Medical Center

Hartford, Connecticut, 06103, United States
H. Lee Moffitt Cancer Center and Research Institute, Coordinating Center

Tampa, Florida, 33612, United States
Holtz Children's Hospital at the University of Miami

Miami, Florida, 33136, United States
Nationwide Children's Hospital

Columbus, Ohio, 43205, United States
Nemours Children's Clinic

Jacksonville, Florida, 32207, United States
Shand's Hospital for Children at the University of Florida

Gainesville, Florida, 32608, United States
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Baltimore, Maryland, 21231, United States
University of Alabama at Birmingham Comprehensive Cancer Center

Birmingham, Alabama, 35294, United States
University of Kentucky

Lexington, Kentucky, 40506, United States
University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, 27599, United States
Vanderbilt - Ingram Cancer Center

Nashville, Tennessee, 37232, United States

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