Cold sore virus engineered to attack breast cancer shows promise in early trial

NCT ID NCT02779855

First seen Nov 01, 2025 · Last updated May 03, 2026 · Updated 21 times

Summary

This study tested whether injecting a modified herpes virus (talimogene laherparepvec) directly into breast tumors, alongside standard chemotherapy before surgery, could destroy more cancer cells in people with triple negative breast cancer. The virus is designed to infect and break open cancer cells while leaving healthy cells alone, and may also help the immune system fight the tumor. The trial enrolled 50 participants and measured the highest safe dose and the rate of complete tumor disappearance after treatment.

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Contacts and locations

Locations

  • H. Lee Moffitt Cancer Center and Research Institute

    Tampa, Florida, 33612, United States

Conditions

Explore the condition pages connected to this study.