Cold sore virus turned cancer assassin shows promise in tough breast cancer

NCT ID NCT02779855

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tested whether injecting a modified herpes virus (T-VEC) directly into tumors, alongside standard chemotherapy before surgery, could better eliminate triple negative breast cancer. The virus is designed to infect and destroy cancer cells while leaving healthy cells alone, and may also help the immune system attack the tumor. The trial enrolled 50 women with early-stage triple negative breast cancer to find the safest dose and measure how many had no cancer left at surgery.

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Conditions

The condition(s) this trial relates to.

breast cancer breast ductal adenocarcinoma breast neoplasm Carcinoma, Ductal invasive breast carcinoma invasive ductal breast carcinoma triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • H. Lee Moffitt Cancer Center and Research Institute

    Tampa, Florida, 33612, United States