Can a tumor test predict aggressive prostate cancer in black men? new study aims to find out

NCT ID NCT02723734

Ongoing Knowledge-focused Sponsor: H. Lee Moffitt Cancer Center and Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether the Decipher test, which predicts how aggressive prostate cancer is, works the same for African-American men as for other men. The test was developed mainly from samples of European men, but African-American men have higher rates of prostate cancer and death from it. Researchers will collect tumor samples from 240 men and see how well the test predicts cancer recurrence within two years. The goal is to help doctors choose the right treatment—avoiding unnecessary side effects for low-risk patients and giving more aggressive therapy to those who need it.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Decipher test (genomic classifier test on tumor samples)
What this could lead to: If successful, this could help doctors better tailor prostate cancer treatment for African-American men, who face higher risks.
What could go wrong: This is an observational validation study, not a treatment trial. The test may not perform equally across groups, and results may not change outcomes directly.

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Conditions

The condition(s) this trial relates to.

prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE CANCER

Contacts and locations

Locations

Bay Pines VA Health care System

Bay Pines, Florida, 33744, United States
H. Lee Moffitt Cancer Center and Research Institute

Tampa, Florida, 33612, United States
James A. Haley VA Hospital

Tampa, Florida, 33612, United States

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