New combo therapy targets breast cancer in the brain and spine
NCT ID NCT04588545
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether radiation therapy followed by injecting two targeted antibodies (trastuzumab and pertuzumab) directly into the spinal fluid is safe and improves survival for people with HER2+ breast cancer that has spread to the lining of the brain and spine. About 33 participants will receive radiation first to ease symptoms and help the drugs flow, then increasing doses of the antibodies. The goal is to find the best dose and see if it extends life by at least one year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- trastuzumab and pertuzumab (given directly into the spinal fluid)
- What this could lead to
- If it works, this could offer a new treatment option for HER2+ breast cancer that has spread to the brain and spine lining, potentially improving survival.
- What could go wrong
- This is an early-phase trial with only 33 participants, so results may not apply to everyone. The treatment involves radiation and spinal injections, which carry risks like infection or nerve damage.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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Northwestern University
Evanston, Illinois, 60208, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a triple drug combo shrink HER2-Positive breast tumors before surgery?
- Can an extra radiation dose keep HER2+ breast cancer at bay?
- Can a pill reach the brain and fight tumors?
- Can a drug cocktail cure metastatic breast cancer? a trial aims to find out
- Can less chemo be enough? a trial challenges standard treatment for HER2-Positive breast cancer
- Can a new drug outsmart resistant breast cancer?