LEPTOMENINGEAL METASTASIS
Clinical trials for LEPTOMENINGEAL METASTASIS explained in plain language.
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New hope for lung cancer patients with brain spread after standard treatment fails
Disease control Recruiting nowThis study tests a new treatment for people with a specific type of lung cancer (EGFR-mutant non-small cell lung cancer) that has spread to the lining of the brain and spinal cord (leptomeningeal metastasis) and has stopped responding to the drug osimertinib. The treatment combin…
Matched conditions: LEPTOMENINGEAL METASTASIS
Phase: PHASE2 • Sponsor: Taipei Veterans General Hospital, Taiwan • Aim: Disease control
Last updated May 17, 2026 03:25 UTC
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Double attack on brain metastases: new combo therapy shows promise for lung cancer patients
Disease control Recruiting nowThis study tests whether adding a chemotherapy drug (pemetrexed) directly into the spinal fluid to a standard targeted therapy pill (like osimertinib) works better than the pill alone for people with a specific type of lung cancer that has spread to the lining of the brain or spi…
Matched conditions: LEPTOMENINGEAL METASTASIS
Phase: NA • Sponsor: Guangzhou Medical University • Aim: Disease control
Last updated May 17, 2026 03:23 UTC
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New chemo delivery method targets brain cancer spread in breast cancer patients
Disease control Recruiting nowThis study tests if giving chemotherapy directly into the fluid around the brain (via a small device called an Ommaya reservoir) along with standard body chemotherapy works better than standard chemotherapy alone for people with HER2-negative breast cancer that has spread to the …
Matched conditions: LEPTOMENINGEAL METASTASIS
Phase: PHASE4 • Sponsor: Fudan University • Aim: Disease control
Last updated May 17, 2026 03:23 UTC
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New hope for brain lining cancer: spinal chemotherapy after targeted drug failure
Disease control Recruiting nowThis study tests a chemotherapy drug called pemetrexed, given directly into the spinal fluid, for people with a specific type of lung cancer that has spread to the lining of the brain and spinal cord. The cancer has stopped responding to a higher dose of a targeted therapy. The g…
Matched conditions: LEPTOMENINGEAL METASTASIS
Phase: PHASE2 • Sponsor: Guangzhou Medical University • Aim: Disease control
Last updated May 15, 2026 11:56 UTC
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New drug cocktail targets breast cancer that invaded the brain
Disease control Recruiting nowThis study tests whether a combination of two oral drugs (tucatinib and capecitabine) plus a chemotherapy given directly into the spinal fluid (trastuzumab) can help people with HER2-positive breast cancer that has spread to the lining of the brain and spinal cord. About 30 adult…
Matched conditions: LEPTOMENINGEAL METASTASIS
Phase: PHASE2 • Sponsor: UNICANCER • Aim: Disease control
Last updated May 15, 2026 11:53 UTC
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New combo therapy aims to fight deadly breast cancer spread to the brain
Disease control Recruiting nowThis study tests if radiation therapy followed by two targeted drugs (trastuzumab and pertuzumab) given directly into the spinal fluid is safe and helps people with HER2+ breast cancer that has spread to the lining of the brain and spinal cord (leptomeningeal disease). About 39 p…
Matched conditions: LEPTOMENINGEAL METASTASIS
Phase: PHASE1, PHASE2 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated May 14, 2026 12:06 UTC
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New drug-radiation combo targets deadly brain metastasis in early trial
Disease control Recruiting nowThis early-phase study tests whether adding the drug azeliragon to radiation therapy is safe for people with cancer that has spread to the lining of the brain and spinal cord (leptomeningeal metastasis). About 32 adults with solid tumors or high-grade gliomas will receive the com…
Matched conditions: LEPTOMENINGEAL METASTASIS
Phase: PHASE1 • Sponsor: NYU Langone Health • Aim: Disease control
Last updated May 14, 2026 12:05 UTC
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New hope for brain-spread lung cancer: spinal fluid drug combo tested
Disease control Recruiting nowThis early-phase study tests whether injecting two drugs (pemetrexed and bevacizumab) directly into the spinal fluid is safe and helps control lung cancer that has spread to the lining of the brain. About 19 adults with this advanced condition will receive the treatment. The goal…
Matched conditions: LEPTOMENINGEAL METASTASIS
Phase: PHASE1 • Sponsor: Shanghai Chest Hospital • Aim: Disease control
Last updated May 13, 2026 16:02 UTC
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New dosing strategy aims to tackle lung cancer brain spread
Disease control Recruiting nowThis study is for people with a specific type of advanced lung cancer (EGFR-mutant NSCLC) that has spread to the lining of the brain (leptomeningeal metastasis). It tests whether taking a higher dose of the drug furmonertinib every other day works better and is safe compared to t…
Matched conditions: LEPTOMENINGEAL METASTASIS
Phase: NA • Sponsor: Guangzhou University of Traditional Chinese Medicine • Aim: Disease control
Last updated May 07, 2026 18:39 UTC
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New combo therapy aims to halt brain-spread lung cancer
Disease control Recruiting nowThis study tests a stronger dose of a targeted cancer pill (EGFR-TKI) combined with two other drugs for people with advanced lung cancer that has spread to the lining of the brain and is no longer responding to standard treatment. About 30 adults will receive this combination to …
Matched conditions: LEPTOMENINGEAL METASTASIS
Phase: NA • Sponsor: Second Affiliated Hospital of Nanchang University • Aim: Disease control
Last updated May 04, 2026 16:23 UTC
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Can a breast cancer drug reach brain tumors? new study aims to find out
Knowledge-focused Recruiting nowThis study looks at how much of the drug T-DXd gets into brain tumors after being injected into the body. It includes 30 adults with brain cancer that has the HER2 protein. Researchers will measure drug levels in the tumor during surgery to see if it could be a useful treatment.
Matched conditions: LEPTOMENINGEAL METASTASIS
Phase: PHASE2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Knowledge-focused
Last updated May 15, 2026 11:57 UTC