LEPTOMENINGEAL METASTASIS

This study is testing a new combination treatment for a serious complication where lung cancer spreads to the lining of the brain and spinal cord. It involves injecting a chemotherapy drug directly into the spinal fluid, alongside a targeted oral medication, for patients whose pr…

This study is testing a chemotherapy drug injected directly into the spinal fluid to treat lung cancer that has spread to the membranes surrounding the brain. It's for patients whose cancer has continued to grow despite receiving high doses of targeted therapy drugs. Researchers …

This trial is testing if a two-part treatment works better than pills alone for a serious complication where lung cancer spreads to the fluid-filled linings of the brain and spinal cord. It will compare standard targeted pills (like osimertinib) against those same pills plus a ch…

This study is testing whether adding chemotherapy delivered directly into the spinal fluid (through a small implanted device called an Ommaya reservoir) works better than standard chemotherapy alone for people with HER2-negative breast cancer that has spread to the membranes surr…

This study aims to find out if the cancer drug trastuzumab deruxtecan (T-DXd) can get into brain tumors when given through an IV. Researchers will measure how much of the drug reaches the tumor during surgery in 30 adults with certain HER2-positive brain cancers or recurrent glio…

This early-stage study is testing a new way to treat a serious complication of lung cancer where it spreads to the lining of the brain and spinal cord. Doctors are injecting two cancer drugs directly into the spinal fluid to see if it is safe and if it helps patients live longer.…

This study is testing a more intensive treatment for people with advanced lung cancer where the disease has spread to the lining of the brain and spinal cord (leptomeningeal metastasis) after their previous targeted therapy stopped working. Researchers want to see if giving a hig…

This study is testing whether radiation therapy followed by targeted cancer drugs delivered directly into the spinal fluid is safe and effective for treating HER2-positive breast cancer that has spread to the lining of the brain and spinal cord. The trial will involve 39 patients…

This early-stage study is testing the safety of combining an oral drug called azeliragon with full brain and spine radiation in patients with aggressive cancer that has spread to the lining of the brain and spinal cord. The main goal is to find out if this combination is safe and…

This study is testing a combination of three drugs to treat a serious complication where HER2-positive breast cancer spreads to the fluid-filled lining around the brain and spinal cord. It aims to see if this approach can help patients live longer and improve their neurological s…