LEPTOMENINGEAL METASTASIS

This was a small, early-phase study designed to test the safety and feasibility of a cancer vaccine (SV-BR-1-GM) combined with the immunotherapy drug pembrolizumab (Keytruda) in patients with solid tumors that had spread to the brain or spinal cord lining. The trial planned to en…

This study tests whether radiation therapy followed by injecting two targeted antibodies (trastuzumab and pertuzumab) directly into the spinal fluid is safe and improves survival for people with HER2+ breast cancer that has spread to the lining of the brain and spine. About 33 pa…

This early-phase study tests whether adding the drug azeliragon to radiation therapy is safe for people whose cancer has spread to the lining of the brain and spinal cord. About 21 adults with solid tumors or aggressive brain cancers will receive the combination. The main goal is…

This study tests a new treatment for leptomeningeal metastasis, a condition where cancer spreads to the lining of the brain and spinal cord. The treatment combines an immune checkpoint inhibitor (a drug that helps the immune system fight cancer) with pemetrexed (a chemotherapy dr…

This early-stage study tests a drug called GDC-0084 given alongside radiation therapy for people whose cancer has spread to the brain and has a specific genetic mutation (PI3K). The main goal is to find the safest dose of the drug and see if the combination helps shrink tumors. O…

This study tests the drug lorlatinib in people with a specific type of lung cancer (ALK-positive) that has spread to the brain or the lining of the brain and spinal cord. The goal is to see how well the drug shrinks these brain tumors. About 41 participants will take lorlatinib o…

This study tests a precise type of radiation called VMAT for people whose cancer has spread to the lining of the brain and spine (leptomeningeal metastasis). The goal is to see if this approach can delay cancer growth in the central nervous system better than older radiation meth…

This early-phase study tests a new way to give immunotherapy drugs (nivolumab and ipilimumab) for patients with lung cancer or melanoma that has spread to the lining of the brain and spinal cord (leptomeningeal metastases). The drugs are given both directly into the spinal fluid …

This study was designed to see if analyzing tiny particles called exosomes in spinal fluid could help doctors diagnose leptomeningeal metastasis—a serious complication where breast cancer spreads to the membranes around the brain and spinal cord. Researchers planned to collect sp…