Cancer vaccine trial for brain tumors pulled before it started
NCT ID NCT07199413
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This was a small, early-phase study designed to test the safety and feasibility of a cancer vaccine (SV-BR-1-GM) combined with the immunotherapy drug pembrolizumab (Keytruda) in patients with solid tumors that had spread to the brain or spinal cord lining. The trial planned to enroll adults whose brain metastases had worsened despite standard treatment. However, the study was withdrawn before any participants were enrolled, so no results are available.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
SV-BR-1-GM vaccine (a whole-cell vaccine that secretes GM-CSF), cyclophosphamide, pembrolizumab (Keytruda), and interferon (Sylatron)
What this could lead to
If it had worked, this could point toward a new way to treat brain metastases from solid tumors by using the immune system to attack cancer cells in the central nervous system.
What could go wrong
This trial was withdrawn before any patients were enrolled, so no data on safety or effectiveness exist. The combination of multiple drugs also raises the risk of serious side effects.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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