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Promising combo therapy for brain lining cancer shows hope in new trial

NCT ID NCT06304441

Recruiting now Disease control Sponsor: Guangzhou Medical University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding a chemotherapy drug (pemetrexed) directly into the spinal fluid, alongside a targeted pill (like osimertinib), works better than the pill alone for people with a specific type of lung cancer that has spread to the brain lining. About 100 adults with EGFR-mutated non-small cell lung cancer and confirmed leptomeningeal metastasis will be enrolled. The goal is to see if the combination improves response rates and survival while monitoring side effects.

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Conditions

The condition(s) this trial relates to.

Meningeal Carcinomatosis neoplastic meningitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LEPTOMENINGEAL METASTASIS

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • The Third People's Hospital of Huizhou (Huizhou Hospital of Guangzhou Medical University)

    RECRUITING

    Huizhou, Guangdong, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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Other studies related to the condition(s) this trial covers.