New drug cocktail targets Hard-to-Treat breast cancer spread to brain
NCT ID NCT05800275
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a combination of two oral chemotherapy drugs (tucatinib and capecitabine) plus a targeted antibody given directly into the spinal fluid (trastuzumab) for people with HER2-positive breast cancer that has spread to the lining of the brain and spinal cord (leptomeningeal metastases). The goal is to see if this treatment improves survival at 12 months. About 30 adults with this condition will participate.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Centre Antoine Lacassagne
RECRUITINGNice, 06189, France
Contact
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Centre François Baclesse
RECRUITINGCaen, 14000, France
Contact
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Centre Georges-François Leclerc
RECRUITINGDijon, 21000, France
Contact
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Centre Henri Becquerel
RECRUITINGRouen, 7600, France
Contact
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Centre Jean Perrin
RECRUITINGClermont-Ferrand, 63011, France
Contact
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Centre Léon Bérard
RECRUITINGLyon, 69008, France
Contact
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Gustave Roussy
RECRUITINGVillejuif, 94805, France
Contact
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Institut Bergonié
WITHDRAWNBordeaux, 33000, France
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Institut Jean Godinot
RECRUITINGReims, 51100, France
Contact
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Institut de cancérologie Strasbourg Europe - ICANS
RECRUITINGStrasbourg, 67200, France
Contact
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Institut régional du Cancer de Montpellier
RECRUITINGMontpellier, 34298, France
Contact