Spinal-Fluid vaccine targets breast cancer cells in the brain
NCT ID NCT07694986
First seen Jul 10, 2026 · Last updated Jul 10, 2026
Summary
This study tests a dendritic cell vaccine given directly into the spinal fluid for people with breast cancer that has spread to the lining of the brain and spinal cord (leptomeningeal disease). The vaccine is combined with either trastuzumab (for HER2-positive cancer) or nivolumab (for HER2-negative cancer). The goal is to find the safest dose and see if the treatment can help people live longer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- dendritic cell vaccine (cDC1) given into the spinal fluid, plus trastuzumab or nivolumab
- What this could lead to
- If successful, this approach could offer a new treatment option for people with breast cancer that has spread to the lining of the brain and spinal cord, a condition with very few effective therapies.
- What could go wrong
- This is an early-phase trial with only 30 participants, so results may not apply to everyone. The treatment involves injections into the spinal fluid, which carries risks like infection or nerve damage.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Moffitt Cancer Center
RECRUITINGTampa, Florida, 33612, United States
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