New hope for brain lining cancer: spinal tap chemo after targeted drug fails

NCT ID NCT06296745

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a chemotherapy drug called pemetrexed, given directly into the spinal fluid, for people with a specific type of lung cancer that has spread to the lining of the brain and spinal cord. The cancer must have gotten worse even after taking a high dose of a targeted therapy like osimertinib. The goal is to see if this treatment is safe and can control the cancer in the brain lining.

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Conditions

The condition(s) this trial relates to.

Meningeal Carcinomatosis neoplastic meningitis non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • The Affiliated Huizhou Hospital, Guangzhou Medical University

    RECRUITING

    Huizhou, Guangdong, 516000, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••