Spinal fluid chemo cocktail targets tough brain cancer spread
NCT ID NCT06663306
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early study tests whether injecting two cancer drugs (pemetrexed and bevacizumab) directly into the spinal fluid is safe for people with a specific type of lung cancer that has spread to the lining of the brain. The trial will enroll 19 adults whose cancer has worsened despite standard treatment. The main goal is to check for side effects, but researchers will also track how long participants live.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- pemetrexed and bevacizumab
- What this could lead to
- If it works, this could point toward a new treatment option for lung cancer that has spread to the lining of the brain, a condition with very few options.
- What could go wrong
- This is a very early phase 1 trial with only 19 people, so it is primarily testing safety, not effectiveness. The drugs are given directly into the spinal fluid, which carries risks like infection or nerve damage.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for LEPTOMENINGEAL METASTASIS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Shanghai Chest Hospital
RECRUITINGShanghai, 200030, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a smart drug home in on Hard-to-Treat cancers?
- Family support may be key to easing lung cancer surgery stress
- Can a drop of blood predict disease years before it strikes?
- Blood, urine, and stool may hold the key to predicting a serious side effect of lung cancer treatment
- Microwave ablation vs. radiotherapy: which Non-Surgical option works best for early lung cancer?
- Spinal injection of dual immunotherapy plus chemotherapy targets cancer spread to brain lining