Shanghai Chest Hospital

This study compares two treatments for small lung spots called ground-glass nodules: freezing them (cryoablation) versus surgical removal. About 160 adults with nodules 8-20mm will be enrolled. The goal is to see which approach better prevents the nodules from coming back or spre…

This study compares two minimally invasive techniques—transthoracic (through the chest wall) and transbronchial (through the airways)—to destroy small lung tumors in people with stage IA lung cancer. About 110 participants will be randomly assigned to one method, and researchers …

This study tests a combination of the drug toripalimab and a freezing technique called cryoablation in people with advanced non-small cell lung cancer whose cancer has started to grow again after initial immunotherapy. The goal is to see if this approach can help control the canc…

This study follows 100 people with stage IIB-III non-small cell lung cancer who are getting robotic-assisted sleeve lobectomy after chemoimmunotherapy. Researchers want to see how often the surgery is unsuccessful (needs open surgery, leaves cancer behind, or causes major complic…

This study tests a new way to treat severe emphysema using heated water vapor (InterVapor) to reduce damaged lung tissue. Researchers want to see if treating smaller, precise areas of the lung works better and is safer than treating larger sections. About 100 adults with severe e…

This early-phase study tests whether injecting two drugs (pemetrexed and bevacizumab) directly into the spinal fluid is safe and can help control lung cancer that has spread to the lining of the brain. It involves 19 adults whose cancer has not responded to standard treatments. T…

This study tests whether combining an immunotherapy drug (toripalimab) with radiation therapy works as well as or better than toripalimab plus chemotherapy before surgery for people with stage II-IIIA non-small cell lung cancer. About 124 adults aged 18-75 with operable tumors wi…

This study is for people with metastatic esophageal squamous cell carcinoma who have not had prior treatment. It tests whether adding low-dose or standard radiotherapy to the usual combination of immunotherapy and chemotherapy can improve outcomes. The trial involves 100 particip…

This study tests whether adding chemotherapy to surufatinib works better than surufatinib alone for people with a rare lung cancer called pulmonary neuroendocrine tumor. About 96 adults aged 18-75 will be split into two groups: one gets the drug combo, the other gets surufatinib …

This study tests whether adjusting treatment based on a simple blood test (ctDNA) can help people with a specific type of advanced lung cancer (EGFR-mutant NSCLC). After initial treatment with osimertinib plus chemotherapy, participants whose blood shows no cancer DNA will either…

This study tests if a robot-assisted scope is as good as a very thin scope (guided by a virtual map) for diagnosing suspicious lung spots. About 186 adults with lung nodules will be randomly assigned to one method. The goal is to see which approach gets a clear diagnosis with few…

This study tests whether combining electroacupuncture (a gentle electrical stimulation of acupuncture points) with a standard anti-nausea drug can better prevent nausea and vomiting after lung cancer surgery. It involves 204 high-risk patients undergoing thoracoscopic lung surger…

This study looks at 400 people with non-small cell lung cancer who had chemotherapy or immunotherapy before surgery. It compares two surgical methods: minimally invasive (keyhole) surgery and open surgery. The goal is to see which approach leads to better recovery and long-term c…

This study follows 200 people with stage IIB-III non-small cell lung cancer who receive chemotherapy and immunotherapy before robotic surgery. Researchers want to see if tumor shrinkage (downstaging) leads to better surgical results, like complete tumor removal and fewer complica…