Shanghai Chest Hospital

This study is for people with a specific type of advanced lung cancer (EGFR mutation-positive). It tests whether using a blood test to monitor cancer DNA can help doctors decide when to pause chemotherapy and continue with only the targeted drug osimertinib. The goal is to keep t…

This study compares two minimally invasive procedures—transthoracic (through the chest wall) and transbronchial (through the airways)—to destroy early-stage lung cancer tumors using heat. About 110 adults with stage IA peripheral lung cancer who cannot or choose not to have surge…

This study tests a new treatment called InterVapor for people with severe emphysema, a serious lung disease. The treatment uses heated water vapor to target and shrink damaged lung areas, making it easier to breathe. The study will compare two different ways of applying the vapor…

This study tests whether adding a freezing treatment (cryoablation) to an immunotherapy drug (toripalimab) can help control advanced non-small cell lung cancer that has started to grow again after initial treatment. About 54 adults with a specific type of lung cancer will receive…

This study tests whether adding low-dose or standard radiotherapy to the usual immunotherapy and chemotherapy can help control metastatic esophageal squamous cell carcinoma. About 100 adults with untreated, advanced cancer will be enrolled. The goal is to see if the combination i…

This phase 3 trial tests whether adding targeted radiation (SBRT) to immunotherapy (toripalimab) and chemotherapy before surgery helps people with stage II-III non-small cell lung cancer live longer without the cancer coming back. About 478 participants will be randomly assigned …

This study compares two treatments for small lung spots called ground-glass nodules: freezing them with a probe (cryoablation) or removing them with surgery. About 160 adults with nodules 8-20mm will be followed for 2 years to see which approach better prevents the nodules from c…

This study tests whether adding chemotherapy to the drug surufatinib works better than surufatinib alone for people with a rare type of lung cancer called pulmonary neuroendocrine tumor. About 96 adults will be randomly assigned to one of two treatment groups. The goal is to see …

This study compares two treatments given before surgery for stage II-IIIA non-small cell lung cancer: immunotherapy (toripalimab) plus radiation versus immunotherapy plus chemotherapy. The goal is to see which combination works better at shrinking tumors and improving surgery out…

This early-phase study tests whether injecting two drugs (pemetrexed and bevacizumab) directly into the spinal fluid is safe and helps control lung cancer that has spread to the lining of the brain. About 19 adults with this advanced condition will receive the treatment. The goal…

This study tests a new surgical technique called septum-guided segmentectomy for people with small (≤2 cm), deep-seated early-stage lung cancer. Instead of removing an entire lung lobe, surgeons use natural lung boundaries to precisely remove only the diseased segment, aiming to …

This study follows 100 people with stage IIB-III non-small cell lung cancer who are getting robotic-assisted sleeve lobectomy after chemoimmunotherapy. Researchers want to see how often the surgery is unsuccessful (needs open surgery, leaves cancer behind, or causes major complic…

This study compares two ways to diagnose small lung nodules: a robotic-assisted bronchoscope and an ultrathin bronchoscope with virtual navigation. About 186 adults with suspicious lung nodules will be randomly assigned to one method. The goal is to see if the robotic approach is…

This study tests whether combining electroacupuncture (a gentle electrical stimulation of acupuncture points) with a standard anti-nausea drug can better prevent nausea and vomiting after lung cancer surgery. It involves 204 high-risk patients undergoing thoracoscopic lung surger…

This observational study is for people with stage IIB-III non-small cell lung cancer who are getting chemotherapy and immunotherapy before surgery. It aims to see if tumor shrinkage (downstaging) from this pre-surgery treatment leads to better results during and after robotic-ass…

This study looks at 400 people with non-small cell lung cancer who had pre-treatment (like chemo or immunotherapy) and then needed a specific type of lung surgery called sleeve lobectomy. Researchers want to see if a less invasive surgery (using small cuts and a camera) works as …

This study is gathering information from 500 people with small cell lung cancer to learn how to personalize treatment using radiation and immunotherapy. Researchers will track how long patients live without their cancer growing and overall survival. The goal is to find the best t…