Shanghai Chest Hospital

This phase 2 trial is testing whether adding the drug QL1706 to standard chemotherapy and radiation can help people with limited-stage small cell lung cancer. QL1706 is a type of immunotherapy that targets two immune checkpoints to help the body fight cancer. The study will enrol…

This study tests whether adding targeted radiation (SBRT) to a standard pre-surgery mix of immunotherapy (toripalimab) and chemotherapy helps people with stage II-III non-small cell lung cancer live longer without the cancer coming back. About 478 adults who have not had prior tr…

This study tests a new surgical technique called septum-guided segmentectomy for people with small, early-stage lung cancer located deep in the lung. The goal is to remove the cancer completely while saving as much healthy lung tissue as possible, which may help preserve breathin…

This study compares two ways to destroy early-stage lung cancer tumors using heat (radiofrequency ablation) without surgery. One method goes through the chest wall, the other through the airways using a bronchoscope. Researchers will check which approach is safer and more effecti…

This study compares two treatments for small lung spots called ground-glass nodules: cryoablation (freezing the nodule) and thoracoscopic surgery (removing it). Researchers want to see which approach is safer and better at preventing the nodules from coming back. About 160 adults…

This study compares two treatments given before surgery for stage II-IIIA non-small cell lung cancer: immunotherapy (toripalimab) plus radiation versus immunotherapy plus chemotherapy. About 124 adults aged 18-75 will take part. The goal is to see which combination works better a…

This early study tests whether injecting two cancer drugs (pemetrexed and bevacizumab) directly into the spinal fluid is safe for people with a specific type of lung cancer that has spread to the lining of the brain. The trial will enroll 19 adults whose cancer has worsened despi…

This study tests whether adding low-dose or standard radiotherapy to the usual combination of immunotherapy (anti-PD-1) and chemotherapy can help people with metastatic esophageal squamous cell carcinoma. About 100 adults who have not had prior treatment will participate. The goa…

This study tests whether adding chemotherapy to surufatinib works better than surufatinib alone for people with a rare lung cancer called pulmonary neuroendocrine tumor. About 96 adults will be randomly assigned to one of two treatment groups. The goal is to see if the combinatio…

This study tests a personalized approach for people with advanced EGFR-mutant lung cancer. After initial treatment with osimertinib plus chemotherapy, doctors will use a blood test (ctDNA) to decide if patients can stop chemotherapy and continue with osimertinib alone, or if they…

This study tests a new way to treat severe emphysema using heated water vapor (InterVapor) to shrink damaged lung tissue. Researchers want to see if treating smaller, targeted areas (subsegments) works better than treating larger sections. 100 adults with severe emphysema will be…

This phase 2 trial is testing whether combining the immunotherapy drug toripalimab with cryoablation (a procedure that freezes and kills tumor cells) can help control advanced non-small cell lung cancer that has started to grow again after initial treatment. The study enrolls 54 …

This study compares two ways to biopsy suspicious lung nodules: a robotic-assisted bronchoscopy and an ultrathin bronchoscope with virtual navigation. About 186 participants will be randomly assigned to one method. The goal is to see if the robotic approach is at least as good at…

This study tests whether combining electroacupuncture (a type of acupuncture with mild electric pulses) with a standard nausea drug can prevent vomiting after lung cancer surgery. The trial will include 204 high-risk patients undergoing thoracoscopic surgery. The main goal is to …

This study is gathering detailed information from 500 people with small cell lung cancer to learn how to tailor treatments like radiation and immunotherapy to each patient. The goal is to find the best timing and doses of radiotherapy to work with immunotherapy, improving outcome…

This study is observing 100 people with stage IIB-III non-small cell lung cancer who have already received chemotherapy and immunotherapy. After that treatment, they will have robotic-assisted sleeve lobectomy (a type of lung surgery). The goal is to see how often the surgery is …

This observational study enrolls 200 people with stage IIB-III non-small cell lung cancer who receive chemo-immunotherapy before robotic surgery. Researchers want to see if tumor and lymph node shrinkage (downstaging) leads to better surgical results, like complete tumor removal …

This study looks at 400 lung cancer patients who had chemotherapy or immunotherapy before surgery. Researchers compare two surgical techniques: minimally invasive (using small cuts and a camera) versus traditional open chest surgery. The goal is to see which approach leads to bet…