Freezing tumors and boosting immunity: new hope for lung cancer?

NCT ID NCT06127303

Recruiting now Disease control Sponsor: Shanghai Chest Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This phase 2 trial is testing whether combining the immunotherapy drug toripalimab with cryoablation (a procedure that freezes and kills tumor cells) can help control advanced non-small cell lung cancer that has started to grow again after initial treatment. The study enrolls 54 adults with stage IV lung cancer who have a limited number of new or growing tumors. The goal is to see if this combination can extend the time before the cancer progresses further.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: toripalimab (immunotherapy drug) and cryoablation (freezing tumors)
What this could lead to: If it works, this combination could offer a new option to control advanced lung cancer that has started to grow again after first-line immunotherapy.
What could go wrong: This is a small, early-phase trial (54 people) with no comparison group, so results may not apply broadly. Cryoablation carries risks like bleeding or infection, and immunotherapy can cause immune-related side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

Shanghai Chest Hospital
RECRUITING

Shanghai, Shanghai Municipality, 200000, China
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
NOT_YET_RECRUITING

Shanghai, China
Zhongshan Hospital, Fudan University
NOT_YET_RECRUITING

Shanghai, China

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