Freezing tumors and boosting immunity: new hope for lung cancer?
NCT ID NCT06127303
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This phase 2 trial is testing whether combining the immunotherapy drug toripalimab with cryoablation (a procedure that freezes and kills tumor cells) can help control advanced non-small cell lung cancer that has started to grow again after initial treatment. The study enrolls 54 adults with stage IV lung cancer who have a limited number of new or growing tumors. The goal is to see if this combination can extend the time before the cancer progresses further.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
toripalimab (immunotherapy drug) and cryoablation (freezing tumors)
What this could lead to
If it works, this combination could offer a new option to control advanced lung cancer that has started to grow again after first-line immunotherapy.
What could go wrong
This is a small, early-phase trial (54 people) with no comparison group, so results may not apply broadly. Cryoablation carries risks like bleeding or infection, and immunotherapy can cause immune-related side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Shanghai Chest Hospital
RECRUITINGShanghai, Shanghai Municipality, 200000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
NOT_YET_RECRUITINGShanghai, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Zhongshan Hospital, Fudan University
NOT_YET_RECRUITINGShanghai, China
Contact Phone: •••-•••-•••• Email: •••••@•••••