Shanghai Chest Hospital

This study tests a new treatment plan for people with advanced non-small cell lung cancer that cannot be removed by surgery. Participants first receive chemotherapy plus immunotherapy, then radiation with more chemo, followed by additional immunotherapy. The goal is to see if thi…

This study tests whether adding a nerve-calming kidney procedure (renal denervation) to standard heart ablation (pulsed-field ablation) can better prevent atrial fibrillation from coming back. About 86 adults with persistent AFib will be randomly assigned to get either the combin…

This phase 2 trial tests a combination of four drugs—pembrolizumab, bevacizumab, pemetrexed, and cisplatin—as a first treatment for people with advanced non-squamous lung cancer that has a specific EGFR exon 20 insertion mutation. The study enrolled 54 participants and measures h…

This study tests a new treatment plan for people with advanced esophageal cancer that cannot be surgically removed. Participants first receive immunotherapy plus chemotherapy, followed by chemoradiation. The goal is to see if this approach improves survival and controls the disea…

This phase 2 trial is testing the targeted drug dacomitinib in 30 people with advanced non-small cell lung cancer that has uncommon EGFR mutations. Participants take a daily pill until their cancer worsens or side effects become too severe. The study aims to see how well the drug…

This study follows 305 people with stage III non-small cell lung cancer who have specific genetic mutations. Researchers regularly test their blood for tiny traces of cancer DNA (minimal residual disease, or MRD) to see if it can predict when the cancer will come back. The goal i…

This study looks at tissue samples from 30 people with esophageal squamous cell carcinoma to see how far the cancer spreads beyond what the surgeon can see. Researchers want to find patterns of hidden tumor growth to help guide future surgeries. Participants have already had thei…